| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | THYROID | -1.305 | 3 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | CERVIX | -1.368 | 3 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | PLEURA | -1.242 | 7 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | ENDOMETRIUM | -1.322 | 16 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | LIVER | -1.356 | 16 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | GANGLIA | -1.385 | 18 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | KIDNEY | -1.215 | 20 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | STOMACH | -1.288 | 20 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | BONE | -1.327 | 23 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | OESOPHAGUS | -1.322 | 24 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | INTESTINE | -1.363 | 25 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | PANCREAS | -1.365 | 26 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | BREAST | -1.346 | 28 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | SOFT_TISSUE | -1.291 | 31 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | SKIN | -1.387 | 36 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | OVARY | -1.408 | 36 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | SYSTEM | -1.301 | 44 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | TRACT | -1.244 | 53 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.326 | 58 |
| 1 | MARS | Methionine--tRNA ligase, cytoplasmic | LUNG | -1.364 | 73 |
| 2 | EEF1G | Elongation factor 1-gamma | CERVIX | -1.017 | 3 |
| 2 | EEF1G | Elongation factor 1-gamma | THYROID | -1.128 | 3 |
| 2 | EEF1G | Elongation factor 1-gamma | PLEURA | -1.166 | 7 |
| 2 | EEF1G | Elongation factor 1-gamma | ENDOMETRIUM | -1.081 | 16 |
| 2 | EEF1G | Elongation factor 1-gamma | LIVER | -1.105 | 16 |
| 2 | EEF1G | Elongation factor 1-gamma | GANGLIA | -1.015 | 18 |
| 2 | EEF1G | Elongation factor 1-gamma | KIDNEY | -1.046 | 20 |
| 2 | EEF1G | Elongation factor 1-gamma | STOMACH | -1.069 | 20 |
| 2 | EEF1G | Elongation factor 1-gamma | BONE | -1.051 | 23 |
| 2 | EEF1G | Elongation factor 1-gamma | OESOPHAGUS | -1.046 | 24 |
| 2 | EEF1G | Elongation factor 1-gamma | SOFT_TISSUE | -1.075 | 31 |
| 2 | EEF1G | Elongation factor 1-gamma | SKIN | -1.062 | 36 |
| 2 | EEF1G | Elongation factor 1-gamma | SYSTEM | -1.054 | 44 |
| 2 | EEF1G | Elongation factor 1-gamma | TRACT | -1.057 | 53 |
| 3 | VARS | Valine--tRNA ligase | CERVIX | -1.197 | 3 |
| 3 | VARS | Valine--tRNA ligase | THYROID | -1.215 | 3 |
| 3 | VARS | Valine--tRNA ligase | PLEURA | -1.372 | 7 |
| 3 | VARS | Valine--tRNA ligase | ENDOMETRIUM | -1.258 | 16 |
| 3 | VARS | Valine--tRNA ligase | LIVER | -1.295 | 16 |
| 3 | VARS | Valine--tRNA ligase | GANGLIA | -1.189 | 18 |
| 3 | VARS | Valine--tRNA ligase | KIDNEY | -1.253 | 20 |
| 3 | VARS | Valine--tRNA ligase | STOMACH | -1.353 | 20 |
| 3 | VARS | Valine--tRNA ligase | BONE | -1.281 | 23 |
| 3 | VARS | Valine--tRNA ligase | OESOPHAGUS | -1.299 | 24 |
| 3 | VARS | Valine--tRNA ligase | INTESTINE | -1.308 | 25 |
| 3 | VARS | Valine--tRNA ligase | PANCREAS | -1.265 | 26 |
| 3 | VARS | Valine--tRNA ligase | BREAST | -1.21 | 28 |
| 3 | VARS | Valine--tRNA ligase | SOFT_TISSUE | -1.28 | 31 |
| 3 | VARS | Valine--tRNA ligase | SKIN | -1.236 | 36 |
| 3 | VARS | Valine--tRNA ligase | OVARY | -1.267 | 36 |
| 3 | VARS | Valine--tRNA ligase | SYSTEM | -1.296 | 44 |
| 3 | VARS | Valine--tRNA ligase | TRACT | -1.247 | 53 |
| 3 | VARS | Valine--tRNA ligase | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.226 | 58 |
| 3 | VARS | Valine--tRNA ligase | LUNG | -1.244 | 73 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | CERVIX | -1.141 | 3 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | THYROID | -1.295 | 3 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | PLEURA | -1.162 | 7 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | ENDOMETRIUM | -1.151 | 16 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | LIVER | -1.163 | 16 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | GANGLIA | -1.237 | 18 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | KIDNEY | -1.064 | 20 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | STOMACH | -1.254 | 20 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | BONE | -1.184 | 23 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | OESOPHAGUS | -1.196 | 24 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | INTESTINE | -1.196 | 25 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | PANCREAS | -1.195 | 26 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | BREAST | -1.128 | 28 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | SOFT_TISSUE | -1.192 | 31 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | SKIN | -1.167 | 36 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | OVARY | -1.171 | 36 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | SYSTEM | -1.195 | 44 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | TRACT | -1.231 | 53 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.155 | 59 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | LUNG | -1.172 | 73 |