The Ligandable Human Proteome

Aminoacyl-tRNA synthetase, class II (D/K/N)

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	KARS	Lysine--tRNA ligase	CERVIX	-1.341	3
1	KARS	Lysine--tRNA ligase	THYROID	-1.395	3
1	KARS	Lysine--tRNA ligase	PLEURA	-1.449	7
1	KARS	Lysine--tRNA ligase	ENDOMETRIUM	-1.569	16
1	KARS	Lysine--tRNA ligase	LIVER	-1.608	16
1	KARS	Lysine--tRNA ligase	GANGLIA	-1.596	18
1	KARS	Lysine--tRNA ligase	STOMACH	-1.502	20
1	KARS	Lysine--tRNA ligase	KIDNEY	-1.539	20
1	KARS	Lysine--tRNA ligase	BONE	-1.64	23
1	KARS	Lysine--tRNA ligase	OESOPHAGUS	-1.542	24
1	KARS	Lysine--tRNA ligase	INTESTINE	-1.573	25
1	KARS	Lysine--tRNA ligase	PANCREAS	-1.584	26
1	KARS	Lysine--tRNA ligase	BREAST	-1.679	28
1	KARS	Lysine--tRNA ligase	SOFT_TISSUE	-1.572	31
1	KARS	Lysine--tRNA ligase	SKIN	-1.587	36
1	KARS	Lysine--tRNA ligase	OVARY	-1.619	36
1	KARS	Lysine--tRNA ligase	SYSTEM	-1.561	44
1	KARS	Lysine--tRNA ligase	TRACT	-1.455	53
1	KARS	Lysine--tRNA ligase	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.665	58
1	KARS	Lysine--tRNA ligase	LUNG	-1.543	73
2	DARS	Aspartate--tRNA ligase, cytoplasmic	CERVIX	-1.182	3
2	DARS	Aspartate--tRNA ligase, cytoplasmic	THYROID	-1.276	3
2	DARS	Aspartate--tRNA ligase, cytoplasmic	PLEURA	-1.186	7
2	DARS	Aspartate--tRNA ligase, cytoplasmic	ENDOMETRIUM	-1.051	16
2	DARS	Aspartate--tRNA ligase, cytoplasmic	LIVER	-1.098	16
2	DARS	Aspartate--tRNA ligase, cytoplasmic	GANGLIA	-1.189	18
2	DARS	Aspartate--tRNA ligase, cytoplasmic	KIDNEY	-1.111	20
2	DARS	Aspartate--tRNA ligase, cytoplasmic	STOMACH	-1.173	20
2	DARS	Aspartate--tRNA ligase, cytoplasmic	BONE	-1.182	23
2	DARS	Aspartate--tRNA ligase, cytoplasmic	OESOPHAGUS	-1.214	24
2	DARS	Aspartate--tRNA ligase, cytoplasmic	INTESTINE	-1.165	25
2	DARS	Aspartate--tRNA ligase, cytoplasmic	PANCREAS	-1.088	26
2	DARS	Aspartate--tRNA ligase, cytoplasmic	BREAST	-1.167	28
2	DARS	Aspartate--tRNA ligase, cytoplasmic	SOFT_TISSUE	-1.081	31
2	DARS	Aspartate--tRNA ligase, cytoplasmic	OVARY	-1.076	36
2	DARS	Aspartate--tRNA ligase, cytoplasmic	SKIN	-1.129	36
2	DARS	Aspartate--tRNA ligase, cytoplasmic	SYSTEM	-1.165	44
2	DARS	Aspartate--tRNA ligase, cytoplasmic	TRACT	-1.108	53
2	DARS	Aspartate--tRNA ligase, cytoplasmic	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.181	59
2	DARS	Aspartate--tRNA ligase, cytoplasmic	LUNG	-1.149	73
3	NARS	Asparagine--tRNA ligase, cytoplasmic	CERVIX	-1.697	3
3	NARS	Asparagine--tRNA ligase, cytoplasmic	THYROID	-1.837	3
3	NARS	Asparagine--tRNA ligase, cytoplasmic	PLEURA	-1.379	7
3	NARS	Asparagine--tRNA ligase, cytoplasmic	ENDOMETRIUM	-1.515	16
3	NARS	Asparagine--tRNA ligase, cytoplasmic	LIVER	-1.598	16
3	NARS	Asparagine--tRNA ligase, cytoplasmic	GANGLIA	-1.51	18
3	NARS	Asparagine--tRNA ligase, cytoplasmic	KIDNEY	-1.484	20
3	NARS	Asparagine--tRNA ligase, cytoplasmic	STOMACH	-1.612	20
3	NARS	Asparagine--tRNA ligase, cytoplasmic	BONE	-1.566	23
3	NARS	Asparagine--tRNA ligase, cytoplasmic	OESOPHAGUS	-1.542	24
3	NARS	Asparagine--tRNA ligase, cytoplasmic	INTESTINE	-1.611	25
3	NARS	Asparagine--tRNA ligase, cytoplasmic	PANCREAS	-1.626	26
3	NARS	Asparagine--tRNA ligase, cytoplasmic	BREAST	-1.476	28
3	NARS	Asparagine--tRNA ligase, cytoplasmic	SOFT_TISSUE	-1.557	31
3	NARS	Asparagine--tRNA ligase, cytoplasmic	SKIN	-1.536	36
3	NARS	Asparagine--tRNA ligase, cytoplasmic	OVARY	-1.578	36
3	NARS	Asparagine--tRNA ligase, cytoplasmic	SYSTEM	-1.565	44
3	NARS	Asparagine--tRNA ligase, cytoplasmic	TRACT	-1.568	53
3	NARS	Asparagine--tRNA ligase, cytoplasmic	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	-1.474	58
3	NARS	Asparagine--tRNA ligase, cytoplasmic	LUNG	-1.56	73