| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | THYROID | -1.428 | 3 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | CERVIX | -1.639 | 3 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | PLEURA | -1.519 | 7 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | LIVER | -1.555 | 16 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | ENDOMETRIUM | -1.588 | 16 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | GANGLIA | -1.575 | 18 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | KIDNEY | -1.459 | 20 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | STOMACH | -1.521 | 20 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | BONE | -1.544 | 23 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | OESOPHAGUS | -1.508 | 24 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | INTESTINE | -1.608 | 25 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | PANCREAS | -1.528 | 26 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | BREAST | -1.571 | 28 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | SOFT_TISSUE | -1.582 | 31 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | SKIN | -1.424 | 36 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | OVARY | -1.569 | 36 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | SYSTEM | -1.494 | 44 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | TRACT | -1.554 | 53 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.573 | 58 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | LUNG | -1.489 | 73 |