| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | ENDOMETRIUM | -1.107 | 16 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | LIVER | -1.282 | 16 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | GANGLIA | -1.357 | 18 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | STOMACH | -1.101 | 20 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | BONE | -1.093 | 23 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | OESOPHAGUS | -1.289 | 24 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | PANCREAS | -1.263 | 26 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | BREAST | -1.105 | 28 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | SOFT_TISSUE | -1.153 | 31 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | OVARY | -1.197 | 36 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | SKIN | -1.245 | 36 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | SYSTEM | -1.153 | 44 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | TRACT | -1.29 | 53 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.148 | 58 |
| 1 | VHL | von Hippel-Lindau disease tumor suppressor | LUNG | -1.191 | 73 |