| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | THYROID | -1.273 | 3 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | CERVIX | -1.302 | 3 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | PLEURA | -1.291 | 7 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | ENDOMETRIUM | -1.241 | 16 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | LIVER | -1.254 | 16 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | GANGLIA | -1.243 | 18 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | STOMACH | -1.178 | 20 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | KIDNEY | -1.285 | 20 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | BONE | -1.28 | 23 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | OESOPHAGUS | -1.352 | 24 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | INTESTINE | -1.21 | 25 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | PANCREAS | -1.331 | 26 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | BREAST | -1.208 | 28 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | SOFT_TISSUE | -1.223 | 31 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | SKIN | -1.141 | 36 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | OVARY | -1.216 | 36 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | SYSTEM | -1.246 | 44 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | TRACT | -1.311 | 53 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | -1.316 | 58 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | LUNG | -1.296 | 73 |