| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Bone | -3.028 | 12 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Large Intestine | -2.851 | 30 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Head and Neck | -2.842 | 34 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Esophagus | -2.796 | 26 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Haematopoietic and Lymphoid | -2.763 | 14 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Skin | -2.758 | 4 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Endometrium | -2.688 | 8 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Kidney | -2.686 | 3 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Central Nervous System | -2.402 | 33 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Ovary | -2.398 | 31 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Stomach | -2.385 | 14 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Peripheral Nervous System | -2.173 | 17 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Pancreas | -2.081 | 23 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Prostate | -2.065 | 3 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Lung | -1.838 | 42 |
| 1 | COPS5 | COP9 signalosome complex subunit 5 | Breast | -1.79 | 25 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Large Intestine | -1.94 | 30 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Head and Neck | -1.913 | 34 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Kidney | -1.851 | 3 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Ovary | -1.723 | 31 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Peripheral Nervous System | -1.65 | 17 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Stomach | -1.635 | 14 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Endometrium | -1.628 | 8 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Haematopoietic and Lymphoid | -1.565 | 14 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Bone | -1.552 | 12 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Esophagus | -1.484 | 26 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Breast | -1.436 | 25 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Lung | -1.349 | 42 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Pancreas | -1.348 | 23 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Prostate | -1.291 | 3 |
| 2 | COPS6 | COP9 signalosome complex subunit 6 | Central Nervous System | -1.08 | 33 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Skin | -3.52 | 4 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Head and Neck | -3.432 | 34 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Esophagus | -3.086 | 26 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Bone | -2.928 | 12 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Large Intestine | -2.906 | 30 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Haematopoietic and Lymphoid | -2.701 | 14 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Pancreas | -2.668 | 23 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Central Nervous System | -2.596 | 33 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Ovary | -2.584 | 31 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Lung | -2.539 | 42 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Breast | -2.293 | 25 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Kidney | -2.254 | 3 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Stomach | -2.161 | 14 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Peripheral Nervous System | -2.132 | 17 |
| 3 | PRPF8 | Pre-mRNA-processing-splicing factor 8 | Endometrium | -2.025 | 8 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Skin | -1.422 | 4 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Bone | -1.202 | 12 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Kidney | -1.198 | 3 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Prostate | -1.134 | 3 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Central Nervous System | -1.111 | 33 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Endometrium | -1.042 | 8 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Breast | -1.02 | 25 |
| 4 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Large Intestine | -1.017 | 30 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Skin | -2.689 | 4 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Large Intestine | -2.476 | 30 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Pancreas | -2.366 | 23 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Head and Neck | -2.325 | 34 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Esophagus | -2.301 | 26 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Bone | -2.186 | 12 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Breast | -2.081 | 25 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Haematopoietic and Lymphoid | -1.979 | 14 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Kidney | -1.878 | 3 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Central Nervous System | -1.829 | 33 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Lung | -1.814 | 42 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Stomach | -1.722 | 14 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Ovary | -1.549 | 31 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Prostate | -1.424 | 3 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Endometrium | -1.411 | 8 |
| 5 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | Peripheral Nervous System | -1.406 | 17 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Haematopoietic and Lymphoid | -3.319 | 14 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Large Intestine | -3.317 | 30 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Bone | -2.946 | 12 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Kidney | -2.487 | 3 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Central Nervous System | -2.434 | 33 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Ovary | -2.413 | 31 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Head and Neck | -2.405 | 34 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Esophagus | -2.348 | 26 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Skin | -2.335 | 4 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Stomach | -2.283 | 14 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Lung | -2.272 | 42 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Peripheral Nervous System | -2.248 | 17 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Endometrium | -2.202 | 8 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Pancreas | -1.96 | 23 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Breast | -1.845 | 25 |
| 6 | EIF3F | Eukaryotic translation initiation factor 3 subunit F | Prostate | -1.685 | 3 |