The Ligandable Human Proteome

Ubiquitin-conjugating enzyme E2

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	UBE2NL	Putative ubiquitin-conjugating enzyme E2 N-like	Bone	-1.364	12
1	UBE2NL	Putative ubiquitin-conjugating enzyme E2 N-like	Skin	-1.103	4
1	UBE2NL	Putative ubiquitin-conjugating enzyme E2 N-like	Head and Neck	-1.091	34
2	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	Head and Neck	-1.323	34
2	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	Bone	-1.083	12
2	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	Endometrium	-1.067	8
2	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	Esophagus	-1.03	26
2	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	Skin	-1.023	4
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Skin	-1.92	4
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Head and Neck	-1.683	34
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Esophagus	-1.276	26
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Prostate	-1.21	3
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Large Intestine	-1.206	30
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Endometrium	-1.142	8
3	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	Stomach	-1.139	14
4	UBE2I	SUMO-conjugating enzyme UBC9	Skin	-4.455	4
4	UBE2I	SUMO-conjugating enzyme UBC9	Bone	-4.105	12
4	UBE2I	SUMO-conjugating enzyme UBC9	Large Intestine	-4.002	30
4	UBE2I	SUMO-conjugating enzyme UBC9	Head and Neck	-3.833	34
4	UBE2I	SUMO-conjugating enzyme UBC9	Esophagus	-3.67	26
4	UBE2I	SUMO-conjugating enzyme UBC9	Breast	-3.656	25
4	UBE2I	SUMO-conjugating enzyme UBC9	Pancreas	-3.523	23
4	UBE2I	SUMO-conjugating enzyme UBC9	Central Nervous System	-3.036	33
4	UBE2I	SUMO-conjugating enzyme UBC9	Haematopoietic and Lymphoid	-2.976	14
4	UBE2I	SUMO-conjugating enzyme UBC9	Stomach	-2.924	14
4	UBE2I	SUMO-conjugating enzyme UBC9	Ovary	-2.799	31
4	UBE2I	SUMO-conjugating enzyme UBC9	Peripheral Nervous System	-2.69	17
4	UBE2I	SUMO-conjugating enzyme UBC9	Prostate	-2.681	3
4	UBE2I	SUMO-conjugating enzyme UBC9	Kidney	-2.661	3
4	UBE2I	SUMO-conjugating enzyme UBC9	Endometrium	-2.603	8
4	UBE2I	SUMO-conjugating enzyme UBC9	Lung	-2.54	42
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Bone	-2.43	12
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Haematopoietic and Lymphoid	-2.298	14
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Head and Neck	-1.894	34
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Stomach	-1.577	14
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Peripheral Nervous System	-1.556	17
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Endometrium	-1.543	8
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Esophagus	-1.494	26
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Pancreas	-1.476	23
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Ovary	-1.352	31
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Large Intestine	-1.294	30
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Central Nervous System	-1.268	33
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Kidney	-1.169	3
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Lung	-1.159	42
5	UBE2M	NEDD8-conjugating enzyme Ubc12	Breast	-1.018	25
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Kidney	-1.565	3
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Prostate	-1.369	3
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Head and Neck	-1.258	34
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Bone	-1.193	12
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Central Nervous System	-1.19	33
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Haematopoietic and Lymphoid	-1.167	14
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Skin	-1.067	4
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Peripheral Nervous System	-1.036	17
6	UBE2D3	Ubiquitin-conjugating enzyme E2 D3	Esophagus	-1.034	26
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Central Nervous System	-1.211	33
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Bone	-1.207	12
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Head and Neck	-1.203	34
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Prostate	-1.159	3
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Kidney	-1.158	3
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Skin	-1.11	4
7	UBE2C	Ubiquitin-conjugating enzyme E2 C	Breast	-1.031	25