The Ligandable Human Proteome

Protein kinase domain

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	CDK11A	Cyclin-dependent kinase 11A	Kidney	-2.01	3
1	CDK11A	Cyclin-dependent kinase 11A	Skin	-1.83	4
1	CDK11A	Cyclin-dependent kinase 11A	Large Intestine	-1.767	30
1	CDK11A	Cyclin-dependent kinase 11A	Head and Neck	-1.714	34
1	CDK11A	Cyclin-dependent kinase 11A	Prostate	-1.616	3
1	CDK11A	Cyclin-dependent kinase 11A	Breast	-1.572	25
1	CDK11A	Cyclin-dependent kinase 11A	Peripheral Nervous System	-1.546	17
1	CDK11A	Cyclin-dependent kinase 11A	Bone	-1.528	12
1	CDK11A	Cyclin-dependent kinase 11A	Pancreas	-1.472	23
1	CDK11A	Cyclin-dependent kinase 11A	Esophagus	-1.451	26
1	CDK11A	Cyclin-dependent kinase 11A	Ovary	-1.424	31
1	CDK11A	Cyclin-dependent kinase 11A	Central Nervous System	-1.418	33
1	CDK11A	Cyclin-dependent kinase 11A	Haematopoietic and Lymphoid	-1.405	14
1	CDK11A	Cyclin-dependent kinase 11A	Lung	-1.376	42
1	CDK11A	Cyclin-dependent kinase 11A	Endometrium	-1.368	8
1	CDK11A	Cyclin-dependent kinase 11A	Stomach	-1.347	14
2	NRBP1	Nuclear receptor-binding protein	Haematopoietic and Lymphoid	-1.886	14
2	NRBP1	Nuclear receptor-binding protein	Head and Neck	-1.651	34
2	NRBP1	Nuclear receptor-binding protein	Large Intestine	-1.375	30
2	NRBP1	Nuclear receptor-binding protein	Stomach	-1.32	14
2	NRBP1	Nuclear receptor-binding protein	Skin	-1.181	4
3	VRK1	Serine/threonine-protein kinase VRK1	Peripheral Nervous System	-1.792	17
3	VRK1	Serine/threonine-protein kinase VRK1	Bone	-1.579	12
3	VRK1	Serine/threonine-protein kinase VRK1	Central Nervous System	-1.177	33
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Head and Neck	-3.411	34
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Haematopoietic and Lymphoid	-2.873	14
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Endometrium	-2.82	8
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Esophagus	-2.806	26
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Large Intestine	-2.701	30
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Pancreas	-2.563	23
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Kidney	-2.555	3
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Stomach	-2.383	14
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Prostate	-2.313	3
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Lung	-2.283	42
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Central Nervous System	-2.234	33
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Ovary	-2.22	31
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Bone	-1.88	12
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Peripheral Nervous System	-1.856	17
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Breast	-1.776	25
4	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Skin	-1.409	4
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Bone	-2.088	12
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Skin	-1.905	4
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Kidney	-1.748	3
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Head and Neck	-1.626	34
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Haematopoietic and Lymphoid	-1.517	14
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Esophagus	-1.504	26
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Peripheral Nervous System	-1.34	17
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Central Nervous System	-1.284	33
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Endometrium	-1.255	8
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Large Intestine	-1.191	30
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Ovary	-1.076	31
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Stomach	-1.059	14
5	TP53RK	EKC/KEOPS complex subunit TP53RK	Prostate	-1.035	3
6	MASTL	Serine/threonine-protein kinase greatwall	Skin	-2.415	4
6	MASTL	Serine/threonine-protein kinase greatwall	Large Intestine	-1.984	30
6	MASTL	Serine/threonine-protein kinase greatwall	Bone	-1.955	12
6	MASTL	Serine/threonine-protein kinase greatwall	Head and Neck	-1.924	34
6	MASTL	Serine/threonine-protein kinase greatwall	Kidney	-1.922	3
6	MASTL	Serine/threonine-protein kinase greatwall	Haematopoietic and Lymphoid	-1.708	14
6	MASTL	Serine/threonine-protein kinase greatwall	Central Nervous System	-1.596	33
6	MASTL	Serine/threonine-protein kinase greatwall	Stomach	-1.465	14
6	MASTL	Serine/threonine-protein kinase greatwall	Peripheral Nervous System	-1.424	17
6	MASTL	Serine/threonine-protein kinase greatwall	Lung	-1.362	42
6	MASTL	Serine/threonine-protein kinase greatwall	Esophagus	-1.34	26
6	MASTL	Serine/threonine-protein kinase greatwall	Prostate	-1.285	3
6	MASTL	Serine/threonine-protein kinase greatwall	Pancreas	-1.181	23
6	MASTL	Serine/threonine-protein kinase greatwall	Endometrium	-1.16	8
6	MASTL	Serine/threonine-protein kinase greatwall	Breast	-1.075	25
6	MASTL	Serine/threonine-protein kinase greatwall	Ovary	-1.064	31
7	AURKB	Aurora kinase B	Skin	-5.12	4
7	AURKB	Aurora kinase B	Bone	-4.355	12
7	AURKB	Aurora kinase B	Esophagus	-4.112	26
7	AURKB	Aurora kinase B	Head and Neck	-4.079	34
7	AURKB	Aurora kinase B	Large Intestine	-3.981	30
7	AURKB	Aurora kinase B	Central Nervous System	-3.668	33
7	AURKB	Aurora kinase B	Kidney	-3.516	3
7	AURKB	Aurora kinase B	Lung	-3.203	42
7	AURKB	Aurora kinase B	Breast	-3.195	25
7	AURKB	Aurora kinase B	Prostate	-3.016	3
7	AURKB	Aurora kinase B	Haematopoietic and Lymphoid	-2.971	14
7	AURKB	Aurora kinase B	Endometrium	-2.927	8
7	AURKB	Aurora kinase B	Ovary	-2.846	31
7	AURKB	Aurora kinase B	Pancreas	-2.777	23
7	AURKB	Aurora kinase B	Peripheral Nervous System	-2.71	17
7	AURKB	Aurora kinase B	Stomach	-2.685	14
8	PLK1	Serine/threonine-protein kinase PLK1	Skin	-4.794	4
8	PLK1	Serine/threonine-protein kinase PLK1	Head and Neck	-4.368	34
8	PLK1	Serine/threonine-protein kinase PLK1	Esophagus	-4.223	26
8	PLK1	Serine/threonine-protein kinase PLK1	Large Intestine	-4.22	30
8	PLK1	Serine/threonine-protein kinase PLK1	Bone	-3.958	12
8	PLK1	Serine/threonine-protein kinase PLK1	Breast	-3.777	25
8	PLK1	Serine/threonine-protein kinase PLK1	Stomach	-3.664	14
8	PLK1	Serine/threonine-protein kinase PLK1	Central Nervous System	-3.632	33
8	PLK1	Serine/threonine-protein kinase PLK1	Lung	-3.535	42
8	PLK1	Serine/threonine-protein kinase PLK1	Pancreas	-3.507	23
8	PLK1	Serine/threonine-protein kinase PLK1	Kidney	-3.438	3
8	PLK1	Serine/threonine-protein kinase PLK1	Ovary	-3.423	31
8	PLK1	Serine/threonine-protein kinase PLK1	Haematopoietic and Lymphoid	-3.341	14
8	PLK1	Serine/threonine-protein kinase PLK1	Endometrium	-3.247	8
8	PLK1	Serine/threonine-protein kinase PLK1	Prostate	-3.232	3
8	PLK1	Serine/threonine-protein kinase PLK1	Peripheral Nervous System	-2.921	17
9	CDK9	Cyclin-dependent kinase 9	Skin	-3.334	4
9	CDK9	Cyclin-dependent kinase 9	Bone	-3.168	12
9	CDK9	Cyclin-dependent kinase 9	Head and Neck	-3.164	34
9	CDK9	Cyclin-dependent kinase 9	Haematopoietic and Lymphoid	-2.935	14
9	CDK9	Cyclin-dependent kinase 9	Kidney	-2.854	3
9	CDK9	Cyclin-dependent kinase 9	Esophagus	-2.783	26
9	CDK9	Cyclin-dependent kinase 9	Central Nervous System	-2.585	33
9	CDK9	Cyclin-dependent kinase 9	Large Intestine	-2.255	30
9	CDK9	Cyclin-dependent kinase 9	Prostate	-2.112	3
9	CDK9	Cyclin-dependent kinase 9	Breast	-2.096	25
9	CDK9	Cyclin-dependent kinase 9	Ovary	-2.047	31
9	CDK9	Cyclin-dependent kinase 9	Pancreas	-2.039	23
9	CDK9	Cyclin-dependent kinase 9	Lung	-2.023	42
9	CDK9	Cyclin-dependent kinase 9	Peripheral Nervous System	-1.907	17
9	CDK9	Cyclin-dependent kinase 9	Stomach	-1.891	14
9	CDK9	Cyclin-dependent kinase 9	Endometrium	-1.784	8
10	CDK7	Cyclin-dependent kinase 7	Esophagus	-2.241	26
10	CDK7	Cyclin-dependent kinase 7	Bone	-1.978	12
10	CDK7	Cyclin-dependent kinase 7	Large Intestine	-1.97	30
10	CDK7	Cyclin-dependent kinase 7	Haematopoietic and Lymphoid	-1.839	14
10	CDK7	Cyclin-dependent kinase 7	Central Nervous System	-1.769	33
10	CDK7	Cyclin-dependent kinase 7	Pancreas	-1.756	23
10	CDK7	Cyclin-dependent kinase 7	Head and Neck	-1.755	34
10	CDK7	Cyclin-dependent kinase 7	Skin	-1.67	4
10	CDK7	Cyclin-dependent kinase 7	Endometrium	-1.662	8
10	CDK7	Cyclin-dependent kinase 7	Peripheral Nervous System	-1.338	17
10	CDK7	Cyclin-dependent kinase 7	Stomach	-1.304	14
10	CDK7	Cyclin-dependent kinase 7	Lung	-1.301	42
10	CDK7	Cyclin-dependent kinase 7	Ovary	-1.176	31
10	CDK7	Cyclin-dependent kinase 7	Breast	-1.148	25
10	CDK7	Cyclin-dependent kinase 7	Kidney	-1.043	3
10	CDK7	Cyclin-dependent kinase 7	Prostate	-1.031	3
11	CSNK1A1	Casein kinase I isoform alpha	Skin	-2.084	4
11	CSNK1A1	Casein kinase I isoform alpha	Kidney	-1.976	3
11	CSNK1A1	Casein kinase I isoform alpha	Peripheral Nervous System	-1.826	17
11	CSNK1A1	Casein kinase I isoform alpha	Prostate	-1.776	3
11	CSNK1A1	Casein kinase I isoform alpha	Haematopoietic and Lymphoid	-1.737	14
11	CSNK1A1	Casein kinase I isoform alpha	Stomach	-1.707	14
11	CSNK1A1	Casein kinase I isoform alpha	Central Nervous System	-1.618	33
11	CSNK1A1	Casein kinase I isoform alpha	Head and Neck	-1.601	34
11	CSNK1A1	Casein kinase I isoform alpha	Ovary	-1.338	31
11	CSNK1A1	Casein kinase I isoform alpha	Large Intestine	-1.321	30
11	CSNK1A1	Casein kinase I isoform alpha	Esophagus	-1.274	26
11	CSNK1A1	Casein kinase I isoform alpha	Bone	-1.23	12
12	TTK	Dual specificity protein kinase TTK	Head and Neck	-1.928	34
12	TTK	Dual specificity protein kinase TTK	Skin	-1.69	4
12	TTK	Dual specificity protein kinase TTK	Large Intestine	-1.544	30
12	TTK	Dual specificity protein kinase TTK	Esophagus	-1.318	26
12	TTK	Dual specificity protein kinase TTK	Endometrium	-1.187	8
12	TTK	Dual specificity protein kinase TTK	Bone	-1.173	12
12	TTK	Dual specificity protein kinase TTK	Kidney	-1.137	3
13	WEE1	Wee1-like protein kinase	Skin	-4.809	4
13	WEE1	Wee1-like protein kinase	Esophagus	-4.287	26
13	WEE1	Wee1-like protein kinase	Kidney	-4.196	3
13	WEE1	Wee1-like protein kinase	Head and Neck	-3.887	34
13	WEE1	Wee1-like protein kinase	Bone	-3.642	12
13	WEE1	Wee1-like protein kinase	Large Intestine	-3.588	30
13	WEE1	Wee1-like protein kinase	Breast	-3.358	25
13	WEE1	Wee1-like protein kinase	Endometrium	-3.194	8
13	WEE1	Wee1-like protein kinase	Central Nervous System	-3.122	33
13	WEE1	Wee1-like protein kinase	Lung	-3.072	42
13	WEE1	Wee1-like protein kinase	Ovary	-3.054	31
13	WEE1	Wee1-like protein kinase	Pancreas	-3.01	23
13	WEE1	Wee1-like protein kinase	Stomach	-2.961	14
13	WEE1	Wee1-like protein kinase	Prostate	-2.912	3
13	WEE1	Wee1-like protein kinase	Haematopoietic and Lymphoid	-2.894	14
13	WEE1	Wee1-like protein kinase	Peripheral Nervous System	-2.883	17
14	CDK1	Cyclin-dependent kinase 1	Skin	-4.251	4
14	CDK1	Cyclin-dependent kinase 1	Head and Neck	-4.187	34
14	CDK1	Cyclin-dependent kinase 1	Large Intestine	-4.04	30
14	CDK1	Cyclin-dependent kinase 1	Bone	-3.944	12
14	CDK1	Cyclin-dependent kinase 1	Esophagus	-3.831	26
14	CDK1	Cyclin-dependent kinase 1	Breast	-3.688	25
14	CDK1	Cyclin-dependent kinase 1	Kidney	-3.677	3
14	CDK1	Cyclin-dependent kinase 1	Central Nervous System	-3.618	33
14	CDK1	Cyclin-dependent kinase 1	Stomach	-3.553	14
14	CDK1	Cyclin-dependent kinase 1	Endometrium	-3.517	8
14	CDK1	Cyclin-dependent kinase 1	Lung	-3.447	42
14	CDK1	Cyclin-dependent kinase 1	Haematopoietic and Lymphoid	-3.28	14
14	CDK1	Cyclin-dependent kinase 1	Ovary	-3.178	31
14	CDK1	Cyclin-dependent kinase 1	Peripheral Nervous System	-3.103	17
14	CDK1	Cyclin-dependent kinase 1	Pancreas	-3.102	23
14	CDK1	Cyclin-dependent kinase 1	Prostate	-2.121	3
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Skin	-1.371	4
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Large Intestine	-1.298	30
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Head and Neck	-1.291	34
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Esophagus	-1.263	26
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Haematopoietic and Lymphoid	-1.15	14
15	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1	Kidney	-1.044	3
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Skin	-3.168	4
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Haematopoietic and Lymphoid	-2.262	14
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Large Intestine	-1.9	30
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Prostate	-1.884	3
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Kidney	-1.805	3
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Esophagus	-1.447	26
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Pancreas	-1.334	23
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Peripheral Nervous System	-1.231	17
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Stomach	-1.223	14
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Head and Neck	-1.204	34
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Bone	-1.078	12
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Central Nervous System	-1.067	33
16	PDPK1	3-phosphoinositide-dependent protein kinase 1	Lung	-1.052	42
17	AURKA	Aurora kinase A	Head and Neck	-1.383	34
17	AURKA	Aurora kinase A	Esophagus	-1.355	26
17	AURKA	Aurora kinase A	Kidney	-1.265	3
17	AURKA	Aurora kinase A	Lung	-1.244	42
17	AURKA	Aurora kinase A	Central Nervous System	-1.165	33
17	AURKA	Aurora kinase A	Endometrium	-1.147	8
17	AURKA	Aurora kinase A	Large Intestine	-1.141	30
17	AURKA	Aurora kinase A	Bone	-1.134	12
17	AURKA	Aurora kinase A	Skin	-1.133	4
17	AURKA	Aurora kinase A	Haematopoietic and Lymphoid	-1.118	14
17	AURKA	Aurora kinase A	Prostate	-1.114	3
17	AURKA	Aurora kinase A	Breast	-1.061	25
17	AURKA	Aurora kinase A	Ovary	-1.022	31
18	CHEK1	Serine/threonine-protein kinase Chk1	Skin	-4.211	4
18	CHEK1	Serine/threonine-protein kinase Chk1	Head and Neck	-3.834	34
18	CHEK1	Serine/threonine-protein kinase Chk1	Esophagus	-3.53	26
18	CHEK1	Serine/threonine-protein kinase Chk1	Kidney	-3.428	3
18	CHEK1	Serine/threonine-protein kinase Chk1	Bone	-3.218	12
18	CHEK1	Serine/threonine-protein kinase Chk1	Central Nervous System	-3.132	33
18	CHEK1	Serine/threonine-protein kinase Chk1	Large Intestine	-3.12	30
18	CHEK1	Serine/threonine-protein kinase Chk1	Haematopoietic and Lymphoid	-3.077	14
18	CHEK1	Serine/threonine-protein kinase Chk1	Lung	-3.052	42
18	CHEK1	Serine/threonine-protein kinase Chk1	Pancreas	-2.913	23
18	CHEK1	Serine/threonine-protein kinase Chk1	Endometrium	-2.794	8
18	CHEK1	Serine/threonine-protein kinase Chk1	Breast	-2.769	25
18	CHEK1	Serine/threonine-protein kinase Chk1	Ovary	-2.683	31
18	CHEK1	Serine/threonine-protein kinase Chk1	Stomach	-2.557	14
18	CHEK1	Serine/threonine-protein kinase Chk1	Peripheral Nervous System	-2.451	17
18	CHEK1	Serine/threonine-protein kinase Chk1	Prostate	-2.45	3
19	PLK4	Serine/threonine-protein kinase PLK4	Large Intestine	-2.638	30
19	PLK4	Serine/threonine-protein kinase PLK4	Bone	-2.561	12
19	PLK4	Serine/threonine-protein kinase PLK4	Peripheral Nervous System	-2.55	17
19	PLK4	Serine/threonine-protein kinase PLK4	Kidney	-2.298	3
19	PLK4	Serine/threonine-protein kinase PLK4	Haematopoietic and Lymphoid	-2.132	14
19	PLK4	Serine/threonine-protein kinase PLK4	Stomach	-1.857	14
19	PLK4	Serine/threonine-protein kinase PLK4	Esophagus	-1.784	26
19	PLK4	Serine/threonine-protein kinase PLK4	Ovary	-1.725	31
19	PLK4	Serine/threonine-protein kinase PLK4	Skin	-1.66	4
19	PLK4	Serine/threonine-protein kinase PLK4	Head and Neck	-1.538	34
19	PLK4	Serine/threonine-protein kinase PLK4	Lung	-1.472	42
19	PLK4	Serine/threonine-protein kinase PLK4	Prostate	-1.418	3
19	PLK4	Serine/threonine-protein kinase PLK4	Breast	-1.378	25
19	PLK4	Serine/threonine-protein kinase PLK4	Pancreas	-1.374	23
19	PLK4	Serine/threonine-protein kinase PLK4	Endometrium	-1.214	8
19	PLK4	Serine/threonine-protein kinase PLK4	Central Nervous System	-1.153	33
20	CDC7	Cell division cycle 7-related protein kinase	Skin	-4.413	4
20	CDC7	Cell division cycle 7-related protein kinase	Head and Neck	-4.146	34
20	CDC7	Cell division cycle 7-related protein kinase	Large Intestine	-3.988	30
20	CDC7	Cell division cycle 7-related protein kinase	Kidney	-3.639	3
20	CDC7	Cell division cycle 7-related protein kinase	Bone	-3.596	12
20	CDC7	Cell division cycle 7-related protein kinase	Esophagus	-3.564	26
20	CDC7	Cell division cycle 7-related protein kinase	Haematopoietic and Lymphoid	-3.444	14
20	CDC7	Cell division cycle 7-related protein kinase	Central Nervous System	-3.322	33
20	CDC7	Cell division cycle 7-related protein kinase	Lung	-3.176	42
20	CDC7	Cell division cycle 7-related protein kinase	Pancreas	-3.164	23
20	CDC7	Cell division cycle 7-related protein kinase	Peripheral Nervous System	-3.152	17
20	CDC7	Cell division cycle 7-related protein kinase	Breast	-3.103	25
20	CDC7	Cell division cycle 7-related protein kinase	Stomach	-3.1	14
20	CDC7	Cell division cycle 7-related protein kinase	Ovary	-3.081	31
20	CDC7	Cell division cycle 7-related protein kinase	Endometrium	-3.016	8
20	CDC7	Cell division cycle 7-related protein kinase	Prostate	-2.22	3