| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Skin | -3.567 | 4 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Head and Neck | -2.559 | 34 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Haematopoietic and Lymphoid | -2.513 | 14 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Kidney | -2.411 | 3 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Bone | -2.324 | 12 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Central Nervous System | -2.112 | 33 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Esophagus | -2.079 | 26 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Large Intestine | -2.02 | 30 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Ovary | -1.992 | 31 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Stomach | -1.991 | 14 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Peripheral Nervous System | -1.923 | 17 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Lung | -1.92 | 42 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Prostate | -1.78 | 3 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Pancreas | -1.722 | 23 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Endometrium | -1.697 | 8 |
| 1 | SUPT6H | Transcription elongation factor SPT6 | Breast | -1.533 | 25 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Kidney | -2.514 | 3 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Head and Neck | -2.266 | 34 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Peripheral Nervous System | -1.999 | 17 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Stomach | -1.656 | 14 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Breast | -1.514 | 25 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Esophagus | -1.502 | 26 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Large Intestine | -1.413 | 30 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Central Nervous System | -1.368 | 33 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Haematopoietic and Lymphoid | -1.188 | 14 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Prostate | -1.119 | 3 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Lung | -1.093 | 42 |
| 2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Endometrium | -1.017 | 8 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Head and Neck | -2.216 | 34 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Kidney | -2.039 | 3 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Esophagus | -1.815 | 26 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Central Nervous System | -1.126 | 33 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Peripheral Nervous System | -1.081 | 17 |
| 3 | GRB2 | Growth factor receptor-bound protein 2 | Stomach | -1.034 | 14 |
| 4 | CRKL | Crk-like protein | Kidney | -1.61 | 3 |
| 4 | CRKL | Crk-like protein | Skin | -1.414 | 4 |
| 4 | CRKL | Crk-like protein | Stomach | -1.37 | 14 |
| 4 | CRKL | Crk-like protein | Central Nervous System | -1.318 | 33 |
| 4 | CRKL | Crk-like protein | Head and Neck | -1.247 | 34 |
| 4 | CRKL | Crk-like protein | Esophagus | -1.197 | 26 |
| 4 | CRKL | Crk-like protein | Endometrium | -1.179 | 8 |
| 4 | CRKL | Crk-like protein | Prostate | -1.127 | 3 |
| 4 | CRKL | Crk-like protein | Lung | -1.067 | 42 |