| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Head and Neck | -2.938 | 34 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Esophagus | -2.86 | 26 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Skin | -2.646 | 4 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Haematopoietic and Lymphoid | -2.562 | 14 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Central Nervous System | -2.527 | 33 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Bone | -2.527 | 12 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Ovary | -2.35 | 31 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Large Intestine | -2.269 | 30 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Lung | -2.1 | 42 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Stomach | -2.061 | 14 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Peripheral Nervous System | -1.843 | 17 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Pancreas | -1.618 | 23 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Endometrium | -1.456 | 8 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Breast | -1.404 | 25 |
| 1 | EIF4E | Eukaryotic translation initiation factor 4E | Prostate | -1.324 | 3 |