| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Kidney | -1.735 | 3 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Bone | -1.702 | 12 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Head and Neck | -1.403 | 34 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Haematopoietic and Lymphoid | -1.303 | 14 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Endometrium | -1.273 | 8 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Large Intestine | -1.215 | 30 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Stomach | -1.191 | 14 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Skin | -1.139 | 4 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Central Nervous System | -1.072 | 33 |
| 1 | SETD1A | Histone-lysine N-methyltransferase SETD1A | Peripheral Nervous System | -1.035 | 17 |