| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Skin | -3.43 | 4 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Endometrium | -3.182 | 8 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Stomach | -2.182 | 14 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Bone | -2.148 | 12 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Pancreas | -2.043 | 23 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Breast | -1.588 | 25 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Haematopoietic and Lymphoid | -1.482 | 14 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Esophagus | -1.46 | 26 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Head and Neck | -1.421 | 34 |
| 1 | LRR1 | Leucine-rich repeat protein 1 | Central Nervous System | -1.395 | 33 |
| 2 | TONSL | Tonsoku-like protein | Bone | -3.124 | 12 |
| 2 | TONSL | Tonsoku-like protein | Skin | -3.023 | 4 |
| 2 | TONSL | Tonsoku-like protein | Head and Neck | -2.854 | 34 |
| 2 | TONSL | Tonsoku-like protein | Large Intestine | -2.786 | 30 |
| 2 | TONSL | Tonsoku-like protein | Haematopoietic and Lymphoid | -2.646 | 14 |
| 2 | TONSL | Tonsoku-like protein | Esophagus | -2.56 | 26 |
| 2 | TONSL | Tonsoku-like protein | Kidney | -2.405 | 3 |
| 2 | TONSL | Tonsoku-like protein | Central Nervous System | -2.4 | 33 |
| 2 | TONSL | Tonsoku-like protein | Lung | -2.249 | 42 |
| 2 | TONSL | Tonsoku-like protein | Prostate | -2.034 | 3 |
| 2 | TONSL | Tonsoku-like protein | Pancreas | -1.981 | 23 |
| 2 | TONSL | Tonsoku-like protein | Endometrium | -1.789 | 8 |
| 2 | TONSL | Tonsoku-like protein | Peripheral Nervous System | -1.713 | 17 |
| 2 | TONSL | Tonsoku-like protein | Ovary | -1.662 | 31 |
| 2 | TONSL | Tonsoku-like protein | Breast | -1.637 | 25 |
| 2 | TONSL | Tonsoku-like protein | Stomach | -1.586 | 14 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Esophagus | -1.744 | 26 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Head and Neck | -1.709 | 34 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Skin | -1.625 | 4 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Bone | -1.386 | 12 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Haematopoietic and Lymphoid | -1.331 | 14 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Central Nervous System | -1.213 | 33 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Lung | -1.169 | 42 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Large Intestine | -1.09 | 30 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Pancreas | -1.053 | 23 |
| 3 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | Peripheral Nervous System | -1.013 | 17 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Skin | -2.084 | 4 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Head and Neck | -1.83 | 34 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Kidney | -1.78 | 3 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Esophagus | -1.756 | 26 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Stomach | -1.446 | 14 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Endometrium | -1.429 | 8 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Bone | -1.399 | 12 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Large Intestine | -1.385 | 30 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Central Nervous System | -1.363 | 33 |
| 4 | PPP1R7 | Protein phosphatase 1 regulatory subunit 7 | Prostate | -1.317 | 3 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Bone | -3.182 | 12 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Large Intestine | -3.056 | 30 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Haematopoietic and Lymphoid | -2.941 | 14 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Esophagus | -2.834 | 26 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Head and Neck | -2.824 | 34 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Pancreas | -2.672 | 23 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Lung | -2.542 | 42 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Skin | -2.524 | 4 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Ovary | -2.45 | 31 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Prostate | -2.416 | 3 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Endometrium | -2.409 | 8 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Kidney | -2.358 | 3 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Peripheral Nervous System | -2.243 | 17 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Stomach | -2.225 | 14 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Central Nervous System | -2.204 | 33 |
| 5 | RANGAP1 | Ran GTPase-activating protein 1 | Breast | -2.167 | 25 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Skin | -5.168 | 4 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Head and Neck | -4.898 | 34 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Esophagus | -4.873 | 26 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Large Intestine | -4.715 | 30 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Bone | -4.543 | 12 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Central Nervous System | -4.173 | 33 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Kidney | -4.154 | 3 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Pancreas | -4.105 | 23 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Breast | -4.03 | 25 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Lung | -3.974 | 42 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Stomach | -3.972 | 14 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Haematopoietic and Lymphoid | -3.963 | 14 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Endometrium | -3.641 | 8 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Ovary | -3.637 | 31 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Prostate | -3.113 | 3 |
| 6 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Peripheral Nervous System | -3 | 17 |