The Ligandable Human Proteome

Dihydrofolate reductase domain

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Haematopoietic and Lymphoid	-2.236	14
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Large Intestine	-2.056	30
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Head and Neck	-1.877	34
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Breast	-1.867	25
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Pancreas	-1.781	23
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Esophagus	-1.631	26
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Lung	-1.631	42
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Bone	-1.618	12
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Stomach	-1.501	14
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Kidney	-1.441	3
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Endometrium	-1.279	8
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Peripheral Nervous System	-1.256	17
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Ovary	-1.207	31
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Skin	-1.202	4
1	DHFRL1	Dihydrofolate reductase 2, mitochondrial	Prostate	-1.106	3
2	DHFR	Dihydrofolate reductase	Haematopoietic and Lymphoid	-3.517	14
2	DHFR	Dihydrofolate reductase	Large Intestine	-2.48	30
2	DHFR	Dihydrofolate reductase	Breast	-2.338	25
2	DHFR	Dihydrofolate reductase	Pancreas	-1.958	23
2	DHFR	Dihydrofolate reductase	Esophagus	-1.834	26
2	DHFR	Dihydrofolate reductase	Stomach	-1.797	14
2	DHFR	Dihydrofolate reductase	Head and Neck	-1.694	34
2	DHFR	Dihydrofolate reductase	Lung	-1.447	42
2	DHFR	Dihydrofolate reductase	Bone	-1.169	12
2	DHFR	Dihydrofolate reductase	Skin	-1.075	4
2	DHFR	Dihydrofolate reductase	Endometrium	-1.025	8