| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Bone | -1.584 | 12 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Kidney | -1.311 | 3 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Haematopoietic and Lymphoid | -1.213 | 14 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Esophagus | -1.095 | 26 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Head and Neck | -1.052 | 34 |
| 1 | LETM1 | Mitochondrial proton/calcium exchanger protein | Peripheral Nervous System | -1.002 | 17 |