| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Skin | -4.966 | 4 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Esophagus | -4.057 | 26 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Large Intestine | -4.035 | 30 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Head and Neck | -3.952 | 34 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Bone | -3.922 | 12 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Kidney | -3.449 | 3 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Breast | -3.413 | 25 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Lung | -3.376 | 42 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Pancreas | -3.335 | 23 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Stomach | -3.252 | 14 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Central Nervous System | -3.172 | 33 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Endometrium | -3.07 | 8 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Ovary | -3.03 | 31 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Prostate | -2.95 | 3 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Peripheral Nervous System | -2.939 | 17 |
| 1 | SARS | Serine--tRNA ligase, cytoplasmic | Haematopoietic and Lymphoid | -2.91 | 14 |
| 2 | GARS | Glycine--tRNA ligase | Skin | -2.914 | 4 |
| 2 | GARS | Glycine--tRNA ligase | Endometrium | -2.597 | 8 |
| 2 | GARS | Glycine--tRNA ligase | Head and Neck | -2.555 | 34 |
| 2 | GARS | Glycine--tRNA ligase | Esophagus | -2.215 | 26 |
| 2 | GARS | Glycine--tRNA ligase | Haematopoietic and Lymphoid | -2.173 | 14 |
| 2 | GARS | Glycine--tRNA ligase | Bone | -2.14 | 12 |
| 2 | GARS | Glycine--tRNA ligase | Large Intestine | -2.046 | 30 |
| 2 | GARS | Glycine--tRNA ligase | Peripheral Nervous System | -1.961 | 17 |
| 2 | GARS | Glycine--tRNA ligase | Stomach | -1.894 | 14 |
| 2 | GARS | Glycine--tRNA ligase | Central Nervous System | -1.894 | 33 |
| 2 | GARS | Glycine--tRNA ligase | Kidney | -1.869 | 3 |
| 2 | GARS | Glycine--tRNA ligase | Prostate | -1.739 | 3 |
| 2 | GARS | Glycine--tRNA ligase | Ovary | -1.684 | 31 |
| 2 | GARS | Glycine--tRNA ligase | Pancreas | -1.623 | 23 |
| 2 | GARS | Glycine--tRNA ligase | Lung | -1.566 | 42 |
| 2 | GARS | Glycine--tRNA ligase | Breast | -1.447 | 25 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Skin | -3.409 | 4 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Bone | -3.213 | 12 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Head and Neck | -2.899 | 34 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Large Intestine | -2.747 | 30 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Kidney | -2.702 | 3 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Esophagus | -2.657 | 26 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Haematopoietic and Lymphoid | -2.413 | 14 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Pancreas | -2.385 | 23 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Ovary | -2.382 | 31 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Central Nervous System | -2.377 | 33 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Stomach | -2.09 | 14 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Peripheral Nervous System | -2.053 | 17 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Lung | -2.015 | 42 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Breast | -1.938 | 25 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Endometrium | -1.817 | 8 |
| 3 | TARS | Threonine--tRNA ligase, cytoplasmic | Prostate | -1.409 | 3 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Bone | -2.958 | 12 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Skin | -2.849 | 4 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Head and Neck | -2.64 | 34 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Esophagus | -2.451 | 26 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Central Nervous System | -2.445 | 33 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Large Intestine | -2.323 | 30 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Ovary | -2.192 | 31 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Haematopoietic and Lymphoid | -2.093 | 14 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Peripheral Nervous System | -2.072 | 17 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Endometrium | -1.981 | 8 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Lung | -1.889 | 42 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Stomach | -1.779 | 14 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Prostate | -1.764 | 3 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Pancreas | -1.762 | 23 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Kidney | -1.625 | 3 |
| 4 | EPRS | Bifunctional glutamate/proline--tRNA ligase | Breast | -1.44 | 25 |