| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | ACTR10 | Actin-related protein 10 | Skin | -3.361 | 4 |
| 1 | ACTR10 | Actin-related protein 10 | Head and Neck | -3.249 | 34 |
| 1 | ACTR10 | Actin-related protein 10 | Esophagus | -3.078 | 26 |
| 1 | ACTR10 | Actin-related protein 10 | Prostate | -2.814 | 3 |
| 1 | ACTR10 | Actin-related protein 10 | Peripheral Nervous System | -2.808 | 17 |
| 1 | ACTR10 | Actin-related protein 10 | Kidney | -2.783 | 3 |
| 1 | ACTR10 | Actin-related protein 10 | Large Intestine | -2.737 | 30 |
| 1 | ACTR10 | Actin-related protein 10 | Central Nervous System | -2.686 | 33 |
| 1 | ACTR10 | Actin-related protein 10 | Bone | -2.659 | 12 |
| 1 | ACTR10 | Actin-related protein 10 | Lung | -2.474 | 42 |
| 1 | ACTR10 | Actin-related protein 10 | Stomach | -2.458 | 14 |
| 1 | ACTR10 | Actin-related protein 10 | Ovary | -2.389 | 31 |
| 1 | ACTR10 | Actin-related protein 10 | Breast | -2.338 | 25 |
| 1 | ACTR10 | Actin-related protein 10 | Endometrium | -2.274 | 8 |
| 1 | ACTR10 | Actin-related protein 10 | Haematopoietic and Lymphoid | -2.107 | 14 |
| 1 | ACTR10 | Actin-related protein 10 | Pancreas | -1.725 | 23 |
| 2 | ACTR6 | Actin-related protein 6 | Haematopoietic and Lymphoid | -2.005 | 14 |
| 2 | ACTR6 | Actin-related protein 6 | Bone | -1.528 | 12 |
| 2 | ACTR6 | Actin-related protein 6 | Head and Neck | -1.378 | 34 |
| 2 | ACTR6 | Actin-related protein 6 | Kidney | -1.141 | 3 |
| 2 | ACTR6 | Actin-related protein 6 | Skin | -1.052 | 4 |
| 3 | ACTR2 | Actin-related protein 2 | Skin | -3.028 | 4 |
| 3 | ACTR2 | Actin-related protein 2 | Kidney | -2.594 | 3 |
| 3 | ACTR2 | Actin-related protein 2 | Head and Neck | -2.193 | 34 |
| 3 | ACTR2 | Actin-related protein 2 | Haematopoietic and Lymphoid | -2.153 | 14 |
| 3 | ACTR2 | Actin-related protein 2 | Stomach | -2.036 | 14 |
| 3 | ACTR2 | Actin-related protein 2 | Ovary | -1.828 | 31 |
| 3 | ACTR2 | Actin-related protein 2 | Lung | -1.789 | 42 |
| 3 | ACTR2 | Actin-related protein 2 | Central Nervous System | -1.674 | 33 |
| 3 | ACTR2 | Actin-related protein 2 | Pancreas | -1.663 | 23 |
| 3 | ACTR2 | Actin-related protein 2 | Esophagus | -1.654 | 26 |
| 3 | ACTR2 | Actin-related protein 2 | Bone | -1.634 | 12 |
| 3 | ACTR2 | Actin-related protein 2 | Large Intestine | -1.625 | 30 |
| 3 | ACTR2 | Actin-related protein 2 | Peripheral Nervous System | -1.431 | 17 |
| 3 | ACTR2 | Actin-related protein 2 | Breast | -1.421 | 25 |
| 3 | ACTR2 | Actin-related protein 2 | Endometrium | -1.394 | 8 |
| 3 | ACTR2 | Actin-related protein 2 | Prostate | -1.083 | 3 |
| 4 | POTEI | POTE ankyrin domain family member I | Head and Neck | -1.282 | 34 |
| 4 | POTEI | POTE ankyrin domain family member I | Kidney | -1.074 | 3 |
| 4 | POTEI | POTE ankyrin domain family member I | Esophagus | -1.029 | 26 |
| 5 | ACTL6A | Actin-like protein 6A | Skin | -3.557 | 4 |
| 5 | ACTL6A | Actin-like protein 6A | Bone | -3.36 | 12 |
| 5 | ACTL6A | Actin-like protein 6A | Haematopoietic and Lymphoid | -3.073 | 14 |
| 5 | ACTL6A | Actin-like protein 6A | Large Intestine | -2.566 | 30 |
| 5 | ACTL6A | Actin-like protein 6A | Head and Neck | -2.406 | 34 |
| 5 | ACTL6A | Actin-like protein 6A | Stomach | -2.313 | 14 |
| 5 | ACTL6A | Actin-like protein 6A | Kidney | -2.296 | 3 |
| 5 | ACTL6A | Actin-like protein 6A | Central Nervous System | -2.201 | 33 |
| 5 | ACTL6A | Actin-like protein 6A | Esophagus | -2.07 | 26 |
| 5 | ACTL6A | Actin-like protein 6A | Prostate | -1.68 | 3 |
| 5 | ACTL6A | Actin-like protein 6A | Breast | -1.539 | 25 |
| 5 | ACTL6A | Actin-like protein 6A | Pancreas | -1.414 | 23 |
| 5 | ACTL6A | Actin-like protein 6A | Lung | -1.411 | 42 |
| 5 | ACTL6A | Actin-like protein 6A | Peripheral Nervous System | -1.298 | 17 |
| 5 | ACTL6A | Actin-like protein 6A | Ovary | -1.284 | 31 |
| 5 | ACTL6A | Actin-like protein 6A | Endometrium | -1.062 | 8 |