The Ligandable Human Proteome

Aminoacyl-tRNA synthetase, class II (D/K/N)

Number	Gene Name	Protein Name	Primary Tissue	Median Essentiality Score	Number of Cell Lines
1	KARS	Lysine--tRNA ligase	Skin	-3.748	4
1	KARS	Lysine--tRNA ligase	Bone	-3.167	12
1	KARS	Lysine--tRNA ligase	Head and Neck	-3.012	34
1	KARS	Lysine--tRNA ligase	Esophagus	-2.846	26
1	KARS	Lysine--tRNA ligase	Large Intestine	-2.606	30
1	KARS	Lysine--tRNA ligase	Kidney	-2.543	3
1	KARS	Lysine--tRNA ligase	Central Nervous System	-2.465	33
1	KARS	Lysine--tRNA ligase	Haematopoietic and Lymphoid	-2.362	14
1	KARS	Lysine--tRNA ligase	Stomach	-2.332	14
1	KARS	Lysine--tRNA ligase	Lung	-2.212	42
1	KARS	Lysine--tRNA ligase	Endometrium	-2.136	8
1	KARS	Lysine--tRNA ligase	Ovary	-2.076	31
1	KARS	Lysine--tRNA ligase	Peripheral Nervous System	-1.991	17
1	KARS	Lysine--tRNA ligase	Pancreas	-1.876	23
1	KARS	Lysine--tRNA ligase	Breast	-1.746	25
1	KARS	Lysine--tRNA ligase	Prostate	-1.559	3
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Bone	-4.18	12
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Head and Neck	-3.962	34
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Skin	-3.817	4
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Esophagus	-3.512	26
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Large Intestine	-3.372	30
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Haematopoietic and Lymphoid	-3.355	14
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Endometrium	-3.346	8
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Stomach	-3.296	14
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Kidney	-3.265	3
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Central Nervous System	-2.973	33
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Lung	-2.868	42
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Ovary	-2.795	31
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Prostate	-2.682	3
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Breast	-2.628	25
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Pancreas	-2.509	23
2	DARS	Aspartate--tRNA ligase, cytoplasmic	Peripheral Nervous System	-2.47	17
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Head and Neck	-4.076	34
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Skin	-3.767	4
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Esophagus	-3.601	26
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Large Intestine	-3.364	30
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Central Nervous System	-3.128	33
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Peripheral Nervous System	-3.119	17
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Bone	-3.106	12
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Haematopoietic and Lymphoid	-3.09	14
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Kidney	-3.03	3
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Pancreas	-3.002	23
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Ovary	-2.795	31
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Stomach	-2.769	14
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Endometrium	-2.619	8
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Lung	-2.598	42
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Breast	-2.245	25
3	NARS	Asparagine--tRNA ligase, cytoplasmic	Prostate	-1.919	3