| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Head and Neck | -4.255 | 34 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Skin | -4.138 | 4 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Large Intestine | -4.04 | 30 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Esophagus | -4.026 | 26 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Kidney | -3.643 | 3 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Breast | -3.497 | 25 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Bone | -3.485 | 12 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Pancreas | -3.303 | 23 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Haematopoietic and Lymphoid | -3.289 | 14 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Lung | -3.251 | 42 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Stomach | -3.164 | 14 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Central Nervous System | -3.096 | 33 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Ovary | -3.052 | 31 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Endometrium | -3.05 | 8 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Peripheral Nervous System | -2.731 | 17 |
| 1 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Prostate | -2.21 | 3 |