| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Skin | -4.482 | 4 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Large Intestine | -4.236 | 30 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Head and Neck | -4.115 | 34 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Kidney | -4.11 | 3 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Esophagus | -4.018 | 26 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Haematopoietic and Lymphoid | -3.597 | 14 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Bone | -3.537 | 12 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Central Nervous System | -3.476 | 33 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Lung | -3.475 | 42 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Pancreas | -3.391 | 23 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Stomach | -3.276 | 14 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Breast | -3.128 | 25 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Endometrium | -3.073 | 8 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Peripheral Nervous System | -3.002 | 17 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Ovary | -2.967 | 31 |
| 1 | VCP | Transitional endoplasmic reticulum ATPase | Prostate | -2.795 | 3 |