| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Large Intestine | -3.874 | 30 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Breast | -3.805 | 25 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Kidney | -3.579 | 3 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Pancreas | -3.325 | 23 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Haematopoietic and Lymphoid | -3.235 | 14 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Head and Neck | -3.068 | 34 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Stomach | -3.011 | 14 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Esophagus | -2.99 | 26 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Skin | -2.806 | 4 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Lung | -2.633 | 42 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Endometrium | -2.492 | 8 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Prostate | -2.487 | 3 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Ovary | -2.2 | 31 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Peripheral Nervous System | -2.099 | 17 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Bone | -1.778 | 12 |
| 1 | MAT2A | S-adenosylmethionine synthase isoform type-2 | Central Nervous System | -1.316 | 33 |