| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | PCNA | Proliferating cell nuclear antigen | Skin | -4.749 | 4 |
| 1 | PCNA | Proliferating cell nuclear antigen | Large Intestine | -4.695 | 30 |
| 1 | PCNA | Proliferating cell nuclear antigen | Head and Neck | -4.135 | 34 |
| 1 | PCNA | Proliferating cell nuclear antigen | Esophagus | -4.124 | 26 |
| 1 | PCNA | Proliferating cell nuclear antigen | Haematopoietic and Lymphoid | -3.876 | 14 |
| 1 | PCNA | Proliferating cell nuclear antigen | Bone | -3.761 | 12 |
| 1 | PCNA | Proliferating cell nuclear antigen | Pancreas | -3.706 | 23 |
| 1 | PCNA | Proliferating cell nuclear antigen | Breast | -3.667 | 25 |
| 1 | PCNA | Proliferating cell nuclear antigen | Kidney | -3.647 | 3 |
| 1 | PCNA | Proliferating cell nuclear antigen | Stomach | -3.621 | 14 |
| 1 | PCNA | Proliferating cell nuclear antigen | Lung | -3.55 | 42 |
| 1 | PCNA | Proliferating cell nuclear antigen | Endometrium | -3.276 | 8 |
| 1 | PCNA | Proliferating cell nuclear antigen | Central Nervous System | -3.228 | 33 |
| 1 | PCNA | Proliferating cell nuclear antigen | Ovary | -3.088 | 31 |
| 1 | PCNA | Proliferating cell nuclear antigen | Prostate | -2.77 | 3 |
| 1 | PCNA | Proliferating cell nuclear antigen | Peripheral Nervous System | -2.504 | 17 |