| Number | Gene Name | Protein Name | Primary Tissue | Median Essentiality Score | Number of Cell Lines |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Bone | -1.814 | 12 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Head and Neck | -1.695 | 34 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Haematopoietic and Lymphoid | -1.481 | 14 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Pancreas | -1.474 | 23 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Peripheral Nervous System | -1.375 | 17 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Central Nervous System | -1.375 | 33 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Kidney | -1.321 | 3 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Esophagus | -1.172 | 26 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Large Intestine | -1.155 | 30 |
| 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Stomach | -1.118 | 14 |