The Ligandable Human Proteome

Tyrosine-protein phosphatase non-receptor type 1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	jgy	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000398a	5qe2	89.58
2	oba	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID	1c85	89.24
3	jjg	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000323a	5qeh	87.05
4	878	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID	1ecv	87.03
5	ota	Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state	5ka1	86.92
6	ota	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID	1c88	86.4
7	982	Crystal structure of PTP1B with Bicyclic Thiophene inhibitor	2azr	86.33
8	ota	Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state	5k9w	85.98
9	ota	Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state	5ka7	85.97
10	opa	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID	1c86	85.75
11	ota	Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state	5ka3	85.29
12	ota	Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state	5kad	84.62
13	col	RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA	1gfy	83.39
14	761	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID	1c84	83
15	opa	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID	1c87	82.6
16	694	Crystal structure of PTP1B with monocyclic thiophene inhibitor	2h4g	80.6
17	guy	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000475a	5qdt	78.77
18	ix1	PTP1B complexed with Isoxazole Carboxylic Acid	1xbo	78.43
19	024	Crystal structure of ptp1b-inhibitor complex	2qbs	78.11
20	234	A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors	1q1m	77.94
21	ota	Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state	5kab	75.02
22	ota	Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state	5ka9	74.29
23	4b3	Crystal structure of ptp1b-inhibitor complex	2qbq	73.35
24	un7	Protein tyrosine phosphatase 1B with sulfamic acid inhibitors	2f71	73.26
25	968	Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b	1onz	73.13
26	un5	Protein tyrosine phosphatase 1B with sulfamic acid inhibitors	2f6z	72.59
27	35b	Crystal structure of PTP1B-inhibitor complex	2zmm	72.22
28	jgs	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000648a	5qe0	71.65
29	dbd	Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid	1l8g	71.47
30	jfv	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000072a	5qdl	69.89
31	429	Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B	1qxk	69.77
32	598	Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.	2b07	68.5
33	iz4	CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR	2vex	67.94
34	410	CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes	2zn7	67.71
35	iz5	CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR	2vey	66.82
36	ize	Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B	2cng	66.32
37	d0p	Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K	6b95	65.42
38	izd	Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics	2cm7	65.11
39	iz3	CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR	2vew	63.57
40	jfy	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000163a	5qdn	61.71
41	964	Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic	1nwl	61.54
42	1cg	CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID	4i8n	60.73
43	f32	Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B	2cnf	60.19
44	f20	Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics	2cma	59.82
45	izb	Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B	2cnh	55.62
46	jpd	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000666a	5qg4	54.42
47	jly	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000194a	5qf3	54.41
48	awd	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000740a	5qde	54.18
49	jn1	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000505a	5qfd	48.92
50	jq7	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000540a	5qga	48.35
51	jj4	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000240a	5qee	47.6
52	jjm	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_PKTTA024495b	5qei	45.73
53	jh1	PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000449a	5qe3	29.09