| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 7w7 | Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide | 5u5t | 88.42 |
| 2 | 7wd | Crystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine | 5u62 | 87.23 |
| 3 | lqd | Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine | 5u69 | 78.24 |
| 4 | 82d | Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 5u8a | 77.86 |
| 5 | 7vv | Crystal structure of EED in complex with 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine | 5u5h | 77.44 |
| 6 | 82g | Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 5u8f | 77.06 |
| 7 | lqd | EED in complex with PRC2 allosteric inhibitor EED709 | 5h15 | 76.45 |
| 8 | lqf | EED in complex with PRC2 allosteric inhibitor EED162 | 5h19 | 76.01 |
| 9 | l9w | EED in complex with a methyl-thiazole | 6sfc | 75.6 |
| 10 | lqe | EED in complex with PRC2 allosteric inhibitor EED210 | 5h17 | 75.48 |
| 11 | l9k | EED in complex with a triazolopyrimidine | 6sfb | 74.55 |
| 12 | 73k | EED in complex with an allosteric PRC2 inhibitor | 5gsa | 74.11 |
| 13 | 73k | Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound | 5wuk | 72.42 |
| 14 | 7xg | Polycomb protein EED in complex with inhibitor: 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide | 5u6d | 70.67 |
| 15 | 6pu | Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED | 5k0m | 69.52 |