| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 15j | Crystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol) | 4heu | 90.53 |
| 2 | 5ay | PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine | 5dh5 | 87.5 |
| 3 | pf9 | Discovery of novel inhibitors of PDE10A | 3hr1 | 86.36 |
| 4 | 4xy | PDE10 complexed with 6-chloro-2-cyclopropyl-5-methyl-N-propyl-pyrimidin-4-amine | 5c29 | 86.03 |
| 5 | 4y2 | PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine | 5c2a | 85.48 |
| 6 | 6dt | Crystal structure of the catalytic domain of human PDE10A complexed with N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine | 5b4k | 85.13 |
| 7 | 2w1 | Crystal Structure of PDE10A with 1H-benzimidazol-2-yl(4-((3-(tetrahydro-2H-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone | 4phw | 84.63 |
| 8 | 2f4 | Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor | 4muw | 84.44 |
| 9 | 5mf | human PDE10A, 8-ethyl-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine, 2.03A, H3, Rfree=22.7% | 5edh | 84.16 |
| 10 | 5m9 | human PDE10A, 6-Chloro-5,8-dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyridine, 2.20A, H3, Rfree=23.5% | 5edi | 84.1 |
| 11 | 4hn | PDE10A in complex with the inhibitor AZ5 | 4ael | 84.09 |
| 12 | jy7 | Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors | 6msc | 83.97 |
| 13 | 540 | Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors | 3sn7 | 83.92 |
| 14 | 2f5 | Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor | 4mvh | 83.82 |
| 15 | 15h | Crystal Structure of PDE10A with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol) | 4hf4 | 83.81 |
| 16 | f03 | Identification and structural characterization of PDE10 fragment inhibitors | 4ajf | 83.68 |
| 17 | pf6 | Discovery of novel inhibitors of PDE10A | 3hqy | 82.93 |
| 18 | 8g3 | Crystal structure of PDE10A in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)et hyl]pyrazolo[1,5-a]pyrimidin-7-ol | 5xui | 82.66 |
| 19 | 546 | Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors | 3sni | 82.14 |
| 20 | 8q7 | Crystal structure of human PDE10A in complex with inhibitor 16d | 5uwf | 81.97 |
| 21 | 4xu | PDE10 complexed with 6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine | 5c2h | 81.66 |
| 22 | ev1 | Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals | 2wey | 81.28 |
| 23 | pfk | Structure of PDE10-inhibitor complex | 3qpn | 81.21 |
| 24 | 0t6 | Potent and Selective Phosphodiesterase 10A Inhibitors | 4fcd | 80.94 |
| 25 | 0t7 | Potent and Selective Phosphodiesterase 10A Inhibitors | 4fcb | 80.36 |
| 26 | c1l | Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | 3ui7 | 79.87 |
| 27 | 6dw | Crystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one | 5b4l | 78.56 |
| 28 | lkf | Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia | 4bbx | 78.48 |
| 29 | 490 | Crystal structure of PDE10A in complex with ASP9436 | 4xy2 | 78.38 |
| 30 | 9g6 | Crystal structure of PDE10A catalytic domain complexed with LHB-6 | 5znl | 77.78 |
| 31 | x4c | Crystal structure of PDE10A in complex with a benzimidazole inhibitor | 3ws8 | 77.36 |
| 32 | 6rc | PDE10a with imidazopyrazine inhibitor | 5k9r | 77.08 |
| 33 | axc | Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation. | 2y0j | 75.66 |
| 34 | pfw | Structure of PDE10-inhibitor complex | 3qpp | 74.05 |
| 35 | 5m6 | human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A | 5ede | 73.32 |
| 36 | 4lp | Crystal structure of the catalytic domain of PDE10A complexed with highly potent and brain-penetrant PDE10A Inhibitor with 2-oxindole scaffold | 5axq | 71.94 |
| 37 | pfh | Crystal structure of the catalytic domain of rat phosphodiesterase 10A | 2ovv | 71.33 |
| 38 | pfj | Crystal structure of the catalytic domain of rat phosphodiesterase 10A | 2ovy | 71.33 |
| 39 | pfr | Structure of PDE10-inhibitor complex | 3qpo | 70.84 |
| 40 | 0jq | PDE10a Crystal Structure Complexed with Novel Inhibitor | 4ddl | 66.58 |
| 41 | 227 | Crystal structure of the catalytic domain of rat phosphodiesterase 10A | 2o8h | 60.5 |