| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 4i5 | Crystal structure of human Sirt2 in complex with ADPR and CHIC35 | 5d7q | 99.25 |
| 2 | 3te | Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide | 4rmh | 98.3 |
| 3 | 8no | Crystal structure of human Sirtuin 2 in complex with a selective inhibitor | 5y5n | 98.03 |
| 4 | a2x | Crystal structure of Sirt2 in complex with selective inhibitor A29 | 5yqm | 97.63 |
| 5 | 5gn | Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+ | 5dy4 | 96.58 |
| 6 | 3tk | Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide | 4rmi | 96.57 |
| 7 | 3te | Human Sirt2 in complex with SirReal2 and NAD+ | 4rmg | 96.32 |
| 8 | l5c | Crystal structure of Sirt2 in complex with selective inhibitor L5C | 5yqo | 94.4 |
| 9 | ocz | Crystal structure of human Sirt2 in complex with ADPR and EX-243 | 5d7p | 94.16 |
| 10 | 5gr | Crystal structure of human Sirt2 in complex with a SirReal probe fragment | 5dy5 | 93.24 |
| 11 | l55 | Crystal structure of Sirt2 in complex with selective inhibitor L55 | 5yqn | 92.54 |
| 12 | 8k9 | Human SIRT2 in complex with a specific inhibitor, NPD11033 | 5y0z | 90.55 |
| 13 | 7kj | Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor | 5mat | 86.93 |