| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 1j9 | Crystals structure of Human Glucokinase in complex with small molecule activator | 4iwv | 95.2 |
| 2 | 1jd | Crystal structure of Human Glucokinase in complex with a small molecule activator. | 4ixc | 94.76 |
| 3 | 926 | Crystal structure of glucokinase-activator complex | 4l3q | 93.71 |
| 4 | 1fw | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide | 4ise | 93.68 |
| 5 | mrk | Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap | 3f9m | 93.23 |
| 6 | mrk | Crystal structure of human glucokinase | 1v4s | 93.11 |
| 7 | 2n8 | Human Glucokinase in complex with a nanomolar activator. | 4no7 | 92.77 |
| 8 | 1fy | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide | 4isg | 92.7 |
| 9 | 1fx | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide | 4isf | 92.33 |
| 10 | mrk | Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP | 3id8 | 90.62 |
| 11 | b84 | Crystal Structure of human glucokinase in complex with a synthetic activator | 3imx | 90.36 |
| 12 | tk1 | Human glucokinase in complex with a synthetic activator | 3h1v | 90.21 |
| 13 | aji | Human glucokinase in complex with a synthetic activator | 3a0i | 90.14 |
| 14 | 0h5 | glucokinase in complex with glucose and ATPgS | 3vey | 89.78 |
| 15 | hkm | Crystal structure of Glucokinase in complex with compound 6 | 6e0e | 89.38 |
| 16 | vo1 | Human Glucokinase in Complex with Novel Amino Thiazole Activator | 4mle | 89.03 |
| 17 | vo2 | Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator | 4mlh | 88.49 |
| 18 | ajb | Human glucokinase in complex with 2-amino benzamide activator | 3fr0 | 88.25 |
| 19 | 3lz | Discovery of 2-Pyridyl Ureas as Glucokinase Activators | 4rch | 87.47 |
| 20 | loi | Human glucokinase in complex with a synthetic activator | 3goi | 86.05 |
| 21 | 0h6 | Glucokinase in complex with glucose and activator | 3vf6 | 84.43 |
| 22 | 0h4 | Glucokinase in complex with an activator and glucose | 3vev | 82.89 |
| 23 | s41 | Crystal structure of human glucokinase in complex with glucose and activator | 4dhy | 81.82 |
| 24 | s41 | Glucokinase in complex with activator and glucose | 3s41 | 81.67 |
| 25 | 8wj | Human glucokinase in complex with novel pyrazole activator. | 5v4x | 80.18 |
| 26 | hkg | Crystal structure of Glucokinase in complex with compound 72 | 6e0i | 71.31 |