The Ligandable Human Proteome

Induced myeloid leukemia cell differentiation protein Mcl-1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	2uu	Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid	4oq5	98.87
2	19h	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design	4hw2	94.13
3	2uv	Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid	4oq6	89.95
4	5x2	Mcl-1 complexed with small molecule inhibitor	5fdo	88.67
5	19h	STRUCTURE OF MBP-MCL1 BOUND TO ligand 2 AT 1.55A	4wmu	86.83
6	19g	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design	4hw3	86.76
7	cjy	Crystal structure of MCL-1 in complex with a BIM competitive inhibitor	6b4l	86.48
8	4m6	Mcl-1 complexed with small molecules	4zbi	85.28
9	lod	Co-crystal structure of Mcl1 with inhibitor	6o6f	84.1
10	loj	Co-crystal structure of Mcl1 with inhibitor	6o6g	83.92
11	4m7	Mcl-1 complexed with small molecules	4zbf	83.59
12	n0s	Crystal structure of Mcl1 with inhibitor 9	6oqc	83.2
13	5wl	Mcl-1 complexed with small molecule inhibitor	5fc4	82.44
14	n0p	Crystal structure of Mcl1 with inhibitor 7	6oqn	80.08
15	n0m	Crystal structure of Mcl1 with inhibitor 8	6oqd	78.41
16	j1n	Structure of human Mcl-1 in complex with thienopyrimidine inhibitor	6qgd	77.66
17	n0j	Co-crystal structure of Mcl1 with inhibitor 10	6oqb	76.56
18	lc3	Crystal structure of Mcl-1 in complex with compound 4	3wix	76.39
19	865	STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A	4wmr	74.99
20	e4q	MCL1 in complex with an indole acid ligand	6fs1	74.47
21	jl8	Structure of Mcl-1 in complex with compound 10d	6qz8	73.94
22	jlb	Structure of MBP-Mcl-1 in complex with compound 7a	6qyk	73.85
23	jlk	Structure of Mcl-1 in complex with compound 8d	6qzb	73.51
24	jle	Structure of Mcl-1 in complex with compound 8b	6qz6	72.82
25	jle	Structure of Mcl-1 in complex with compound 8a	6qz5	72.77
26	jkq	Structure of MBP-Mcl-1 in complex with compound 6a	6qxj	72.43
27	jl8	Structure of MBP-Mcl-1 in complex with compound 10d	6qyn	71.26
28	cn7	Crystal structure of MCL-1 in complex with a BIM competitive inhibitor	6b4u	70.93
29	jle	Structure of MBP-Mcl-1 in complex with compound 8b	6qz7	70.59
30	jle	Structure of MBP-Mcl-1 in complex with compound 8a	6qyl	70.22
31	865	STRUCTURE OF MBP-MCL1 BOUND TO ligand 1 AT 2.35A	4wmt	69.07
32	jlh	Structure of MBP-Mcl-1 in complex with compound 18a	6qyo	63.36
33	jl5	Structure of Mcl-1 in complex with compound 13	6qyp	63.28