SGC's E3Hub. An online tool to explore human E3 ligases

comments/feature requests: matthieu.schapira@utoronto.ca

Target Class E1 E2 Multi-subunit E3 ligases Simple E3 ligases NON USP USP Involved in UPS
Involved in UPS: Indicates the confidence level that a protein is involved in the ubiquitin proteasome system.
"degrad" found in Uniprot function: 1 point.
"degrad" found in Reactome pathway(s): 1 point.
"degrad" found in Reactome pathway enriched among biogrid interactors [pathway must be found in at least 3 interactors and enriched at least 3 fold compared with proteome]: 1 point
Any     confidence >=1     confidence >=2     confidence >=3

Options
Sub-Families
Sub-family classification based on https://doi.org/10.1371/journal.pone.0001487 and https://www-sciencedirect-com.myaccess.library.utoronto.ca/science /article/pii/S1097276507003619
Essentially in cancer
Essentiality in cancer: derived from CRISPR knock-out in 341 cell lines from 30 cancer types. The gene is essential in a given cell line if Score < -1.0. Numbers shown are median values of essentiality scores for all cell lines representing a given cancer type. CRIPSR data from https://portals.broadinstitute.org/achilles (Meyers et al. Nature Genetics 2017.DOI: 10.1038/ng.3984)

     Essentiality score lower than
    
Protein Levels in Normal Tissues: Expression profiles for proteins in human tissues based on immunohistochemisty using tissue micro arrays. Data from The Human Protein Atlas version 18. www.proteinatlas.org and DOI: 10.1126/science.1260419.

Tissue:

Cell Type

Protein Level: High    Medium    Low    Not detected
Reliability: Approved    Enhanced    Supported    Uncertain High    Medium    Low
in    of normal tissues
Reliability: Approved    Enhanced    Supported    Uncertain
Protein Levels in Tumors:Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro arrays. Data from The Human Protein Atlas version 18. www.proteinatlas.org and DOI: DOI: 10.1126/science.aan2507

Cancer Type

Protein Level: High    Medium    Low    Not detected High    Medium    Low
in    of tumors



Most symbols on the trees are clickable.
Trees are generated with this script.
| Full Length FASTA File | Full Length Alignment File | Domain Alignment File
The phylogeny outlined in the tree is derived from a CLUSTALW multiple sequence alignment of the full-length sequence of the default Swiss-Prot variant.