The Ligandable Human Proteome

Cathepsin K

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	3fc	Cathepsin K complexed with a constrained ketoamide inhibitor	1yt7	0.13
2	2ca	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR	1nlj	0.16
3	7as	Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.	5tdi	0.18
4	o75	Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.	3o1g	1
5	cke	Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K	2r6n	1
6	0lc	Cathepsin K inhibitor	4dmy	1
7	i10	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR	1bgo	3.5
8	ihi	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491	1u9w	3.5
9	kwz	Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor	3kwz	4
10	ihe	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854	1u9v	6
11	ihj	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688	1u9x	7
12	o96	Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead	3ovz	8.7
13	3y1	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6i	10
14	pos	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PROPANONE INHIBITOR	1au2	13
15	4pr	Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor	2bdl	15
16	3y2	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.	4x6j	16
17	orh	Structure of CatK covalently bound to a dioxo-triazine inhibitor	3kwb	17
18	kx1	Cathepsin K in complex with a selective 2-cyano-pyrimidine inhibitor	3kx1	100