The Ligandable Human Proteome

Aurora kinase A

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	5vc	Crystal Structure of Aurora A Kinase Domain Bound to MK-5108	5ew9	0.01
2	eml	Aurora A Kinase complexed with SCH 1473759	3myg	0.02
3	hpm	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor	2c6e	0.8
4	0c6	Aurora A in complex with YL5-81-1	3uok	0.8
5	zzl	Aurora-A Inhibitor Structure	2wtv	1.8
6	l0g	Structure determination of Aurora Kinase in complex with inhibitor	2w1g	3
7	0c7	Aurora A in complex with SO2-162	3uol	3.1
8	ak8	Structure of AuroraA with pyridyl-pyrimidine urea inhibitor	3efw	4
9	0fy	Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity	3vap	4
10	y3m	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uyn	4
11	45b	Aurora A in complex with a bisanilinopyrimidine	3h0z	4.3
12	zzl	STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054	2x81	5
13	4rj	Human Aurora A catalytic domain bound to FK1141	4ztr	5
14	vx6	Crystal structure of Aurora A in complex with VX-680 and TPX2	3e5a	5.9
15	l0f	Structure determination of Aurora Kinase in complex with inhibitor	2w1f	5.9
16	48b	Aurora A in complex with a bisanilinopyrimidine	3h0y	6
17	fh3	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byi	9
18	x6d	Aurora-A bound to an inhibitor	2x6d	12
19	l0e	Structure determination of Aurora Kinase in complex with inhibitor	2w1e	12
20	0c4	Aurora A in complex with RPM1722	3uoh	13
21	627	Structure of Aurora-2 in complex with PHA-739358	2j50	13
22	0by	Aurora A in complex with YL5-083	3uo6	15
23	vek	Complex of Aurora-A bound to an Imidazopyridine-based inhibitor	4b0g	15
24	0bz	Aurora A in Complex with RPM1679	3unz	16
25	d37	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r22	17
26	ak1	Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]- thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea	3d14	22
27	wph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbo	24
28	4rk	Human Aurora A catalytic domain bound to FK1142	4zts	25
29	mpy	Aurora-2 T287D T288D complexed with PHA-680632	2bmc	27
30	0k6	Structure of Aurora A mutant bound to Biogenidec cpd 15	4dhf	28
31	400	AURORA-A T288E COMPLEXED WITH PHA-828300	2xru	31
32	p9j	Aurora A kinase domain with phthalazinone pyrazole inhibitor	3p9j	31
33	mmh	Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity	3fdn	33
34	nl4	Aurora A kinase bound to an imidazopyridine inhibitor (14a)	5aaf	36
35	0bx	Aurora A in complex with YL1-038-31	3uo5	39
36	0c8	Aurora A in complex with RPM1686	3up2	40
37	yph	Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	4jbp	41
38	cc3	Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors	2np8	42
39	aki	Crystal Structure of Aurora A Kinase complexed with inhibitor	3m11	43
40	6f2	Aurora A kinase bound to an imidazopyridine inhibitor (14b)	5aag	46
41	cj5	Aurora A in complex with CD532	4j8m	48
42	0c3	Aurora A in complex with RPM1693	3uod	49
43	0c5	Aurora A in complex with RPM1715	3uoj	51
44	9yq	Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)	5one	52
45	a0h	Structure of Aurora-A bound to a selective imidazopyrazine inhibitor	2xng	60
46	626	Structure of Aurora-2 in complex with PHA-680626	2j4z	65
47	2vu	Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)	4prj	72
48	d36	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)	3r21	180
49	nhi	Aurora A in complex with YL1-038-18	4dea	256
50	fh5	Aurora A kinase bound to a highly selective imidazopyridine inhibitor	4byj	270
51	0c0	Aurora A in complex with RPM1680	3uo4	299
52	pfq	Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor	3k5u	309
53	4rm	Human Aurora A catalytic domain bound to FK932	4ztq	480
54	2jz	Crystal structure of aurora A in complex with TPX2 and compound 10	3ha6	2100
55	fxg	Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering	3daj	2900
56	jve	SAR156497 an exquisitely selective inhibitor of Aurora kinases	4uzh	9800
57	a4w	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5orl	1.5e+004
58	9qk	Aurora A kinase in complex with 2-(3-fluorophenyl)quinoline-4-carboxylic acid and ATP	5obj	1.65e+004
59	ofi	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor	3lau	3e+004
60	a8h	Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment	5os4	1.665e+006