The Ligandable Human Proteome

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Serine/threonine-protein kinase B-raf

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
1sm5Pyrazole-based inhibitors of B-Raf kinase3d4q0.03
2215Structure of the B-Raf kinase domain bound to SB-5908852fb80.16
38enCrystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor6b8u0.2
4fniHuman B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor3ppk1.4
5fp3Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor3prf1.4
6l1eB-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor3idp1.6
71suCrystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-6324ksp1.6
8p06B-RAF in complex with Dabrafenib5csw4
9904B-Raf Kinase V600E oncogenic mutant in complex with PLX79044xv14.2
10p06B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib4xv25.4
1154jCRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 8823705csx6
12p02B-Raf Kinase V600E oncogenic mutant in complex with PLX79224xv312
13baxThe complex of wild type B-RAF and BAY439006.1uwh22
14831The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor3ii524
15032B-Raf Kinase V600E oncogenic mutant in complex with PLX40323og731
160t2Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor4fc069
175xjB-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor5fd290
18324B-Raf Kinase in Complex with PLX47203c4c160
196n9BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM5jrq169
201ooB-Raf Kinase domain in complex with PLX55684xv9190