The Ligandable Human Proteome

Cyclin-dependent kinase 2

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	cdk	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xmy	0.11
2	frt	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b	2w05	1
3	529	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529	2bpm	2
4	i19	CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b	2w17	2
5	wxv	Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor	2wxv	2
6	i1p	CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE	1urw	3
7	lia	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor	2fvd	3
8	ns9	Crystal structure of CDK2 in complex with inhibitor BS-194	3ns9	3
9	lz9	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtp	3
10	3i6	Crystal Structure of CDK2 in complex with pan-CDK Inhibitor	4bgh	4
11	ls2	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE	1ke6	5.7
12	4sp	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6o	6
13	4sp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102	1h1s	6
14	d42	Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562	2b52	8
15	889	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing	2wpa	8
16	ls3	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE	1ke7	8.9
17	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw9	8.9
18	scj	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3j	10
19	scx	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3m	10
20	o1z	CDK2 in complex with inhibitor RC-2-22	3rah	12
21	im9	CDK2 in complex with an imidazole piperazine	2vv9	17
22	d05	Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305	2b54	20
23	u32	STRUCTURE OF CDK2 COMPLEXED WITH PNU-230032	2bts	20
24	x40	CDK2 in complex with inhibitor RC-2-38	3qu0	20
25	740	Crystal structure of a 3-aminoindazole compound with CDK2	2r64	30
26	lzc	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vts	30
27	hdy	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oir	32
28	st8	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR	1ogu	34
29	292	Structure of CDK2/Cyclin A with PNU-292137	1vyw	37
30	6zk	Structure of phopsho-CDK2-cyclin A in complex with an ATP-competitive inhibitor	5lmk	37
31	nnn	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1	3dog	40
32	404	Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.	3pj8	40
33	lzd	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtt	44
34	nu5	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271	2g9x	45
35	p48	STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125	2wih	45
36	lze	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vu3	47
37	i17	CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717	1g5s	48
38	56h	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032)	5d1j	48
39	ck9	Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor	2a0c	50
40	x42	CDK2 in complex with inhibitor RC-2-36	3qtz	50
41	l0f	Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity	2w1h	52
42	ct9	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor	1y91	59
43	ck5	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxm	60
44	1yg	Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide	4lyn	60
45	efp	Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2	3ig7	63
46	n41	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiy	64
47	efq	Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2	3igg	66.5
48	n20	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oi9	69
49	26z	CDK2 in complex with inhibitor RC-2-88	3rpv	70
50	ck6	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxn	70
51	scz	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3n	70
52	1n3	Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative	3uli	70
53	rc8	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8	3ddp	72
54	6qb	Crystal Structure of CDK2 in complex with compound 22	5k4j	77.5
55	frv	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c	2w06	83
56	371	Structure of CDK2 with a 3-hydroxychromones	2duv	87
57	3qs	CDK2 with EGFR inhibitor compound 8	4rj3	93
58	u73	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873	2btr	95
59	d31	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312	2b55	96
60	04z	CDK2 in complex with inhibitor RC-2-34	3ral	100
61	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR	2iw8	103
62	t7z	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcm	123
63	03z	CDK2 in complex with inhibitor RC-2-32	3rak	130
64	qq2	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw6	140
65	lz8	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vto	140
66	lza	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtq	140
67	tjf	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcq	147
68	y8l	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xnb	149
69	08z	CDK2 in complex with inhibitor RC-2-71	3rk7	200
70	7yg	CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE	4acm	210
71	n76	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiu	210
72	rrc	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine	3ddq	210
73	1qk	The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.	5l2w	210
74	dt4	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6l	270
75	n5b	Structure of CDK2 complexed with PNU-181227	1vyz	290
76	2kd	Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor	4nj3	300
77	dt5	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6m	350
78	12z	CDK2 in complex with inhibitor RC-2-73	3rkb	380
79	pm1	Crystal structure of CDK2 with inhibitor	1pye	386
80	rrc	Human cyclin-dependent kinase 2 in complex with roscovitine	2a4l	400
81	sc8	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3f	500
82	4sp	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102	4eor	500
83	sq9	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfw	510
84	09z	CDK2 in complex with inhibitor RC-2-74	3rk9	520
85	ls1	CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide	1ke5	560
86	628	Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor	1ykr	560
87	d23	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325	2b53	600
88	2sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3o	600
89	x3a	CDK2 in complex with inhibitor RC-2-13	3qtw	650
90	ls5	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	1ke9	660
91	lz3	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vti	660
92	dt2	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6k	730
93	sc9	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3g	800
94	lz7	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtn	850
95	3sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3p	900
96	x36	CDK2 in complex with inhibitor RC-1-148	3qtr	930
97	2a6	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094	1h1q	1000
98	ls4	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE	1ke8	1000
99	scf	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3i	1000
100	dtq	THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di8	1000
101	nw1	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027	1e1x	1300
102	55s	CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)	5cyi	1310
103	z68	CDK2 in complex with inhibitor RC-2-21	3r9n	1400
104	blz	Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor	2i40	1580
105	lz4	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design	2vtj	1900
106	u55	The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide	1jsv	2000
107	i73	Crystal structure of CDK2 in complex with inhibitor ICEC0943	5jq8	2000
108	6cp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086	1h1r	2300
109	i74	Crystal structure of CDK2 in complex with inhibitor ICEC0942	5jq5	2341
110	a07	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor	3lfs	2500
111	hdu	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oiq	2900
112	x35	CDK2 in complex with inhibitor RC-1-137	3qtq	3100
113	x46	CDK2 in complex with inhibitor RC-2-12	3qts	3100
114	a27	Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor	3lfn	3160
115	07z	CDK2 in complex with inhibitor RC-2-72	3rk5	4000
116	27z	CDK2 in complex with inhibitor RC-2-40	3rpy	4800
117	99z	CDK2 in complex with inhibitor RC-3-96	3sqq	4800
118	olo	Crystal structure of human CDK2 in complex with the inhibitor olomoucine.	1w0x	5000
119	z31	CDK2 in complex with inhibitor RC-1-132	3r8u	5000
120	06z	CDK2 in complex with inhibitor L4-12	3rjc	5700
121	4sp	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102	4eok	8600
122	ezr	CDK-2 with indazole inhibitor 17 bound at its active site	3ezr	1e+004
123	dt1	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6i	1.1e+004
124	0bx	CDK2 in complex with inhibitor YL1-038-31	3unj	1.1e+004
125	cmg	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058	1e1v	1.2e+004
126	cmg	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058	1h1p	1.2e+004
127	z60	CDK2 in complex with inhibitor L4-14	3s00	1.2e+004
128	207	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[cyclohex-3-enyl]methoxypurine	1h0w	1.3e+004
129	x02	CDK2 in complex with inhibitor L4	3qqk	1.5e+004
130	0by	CDK2 in complex with inhibitor YL5-083	3unk	1.5e+004
131	56z	CDK2 in complex with inhibitor RC-2-39	3s1h	1.7e+004
132	4qe	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfm	1.82e+004
133	sce	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3h	2e+004
134	fal	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h01	2.2e+004
135	pdy	Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor	3wbl	2.3e+004
136	75x	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfv	2.36e+004
137	ct8	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c69	2.6e+004
138	byp	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h08	2.8e+004
139	50z	CDK2 in complex with inhibitor RC-1-138	3s0o	3.3e+004
140	3fp	CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR	1v1k	3.5e+004
141	fap	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	3.8e+004
142	fcp	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	3.8e+004
143	z63	CDK2 in complex with inhibitor RC-1-136	3r8z	4.9e+004
144	rfz	CDk2/cyclinA in complex with DRB	3my5	6.5e+004
145	x6b	CDK2 in complex with inhibitor RC-2-135	3r9d	7.1e+004
146	20z	CDK2 in complex with inhibitor RC-2-33	3rmf	8.2e+004
147	z71	CDK2 in complex with inhibitor RC-2-143	3r9o	1e+005
148	z67	CDK2 in complex with inhibitor RC-2-142	3r9h	1e+005
149	2wc	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfu	1e+005
150	b49	CDK2 in complex with SUNITINIB	3ti1	1.3e+005