The Ligandable Human Proteome

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Macrophage colony-stimulating factor 1 receptor

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
1krlcFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide3krl0.8
2krjcFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide3krj1.1
38c5cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor3dpk4.1
4ixhcFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor3bea7
55cncFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor2i0y24
6bdyInhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R3lcd40
764mCrystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME4hw762
86c3c-FMS tyrosine kinase in complex with a quinolone inhibitor2i0v160