| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | f62 | Crystal structure of EGFR 696-1022 T790M in complex with XTF-262 | 5gmp | 0.8 |
| 2 | 60d | EGFR kinase domain mutant ""TMLR"" with 3-carboxamide azaindole compound 13 | 5hcy | 1.2 |
| 3 | 4zq | EGFR kinase domain mutant ""TMLR"" with compound 41a | 5cas | 1.4 |
| 4 | 4zr | EGFR kinase domain mutant ""TMLR"" with compound 41b | 5cau | 1.6 |
| 5 | aee | Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 | 2itt | 1.7 |
| 6 | 5n3 | EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine | 5edq | 2 |
| 7 | 633 | EGFR (L858R, T790M, V948R) in complex with N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | 5hg5 | 2 |
| 8 | 8bp | Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | 5ug8 | 2 |
| 9 | ire | Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa | 2itz | 2.6 |
| 10 | 4zj | EGFR kinase domain mutant ""TMLR"" with compound 33 | 5caq | 2.7 |
| 11 | fmm | EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 | 1xkk | 3 |
| 12 | 634 | EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide | 5hg8 | 3 |
| 13 | 5q3 | EGFR kinase domain mutant ""TMLR"" with pyridone compound 19: 4-[(2-azanylpyrimidin-4-yl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide | 5em6 | 4 |
| 14 | 630 | EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988) | 5hg7 | 4 |
| 15 | 60b | EGFR kinase domain mutant ""TMLR"" with azabenzimidazole compound 7 | 5hcx | 4.1 |
| 16 | 80u | Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34 | 5gnk | 5.3 |
| 17 | ire | Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib | 3ug2 | 5.6 |
| 18 | w2r | EGFR kinase domain with compound4 | 3w2s | 6.9 |
| 19 | kj8 | Crystal structure of EGFR kinase domain in complex with compound 4b | 4jq8 | 8 |
| 20 | 8am | Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | 5ug9 | 8 |
| 21 | aee | Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 | 2itp | 11.3 |
| 22 | 8bs | Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | 5ugc | 13 |
| 23 | pox | X-ray structure of EGFR in complex with oxime inhibitor | 3bel | 14 |
| 24 | 0un | Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002 | 3ika | 14 |
| 25 | 3qw | EGFR kinase (T790M/L858R) with inhibitor compound 6 | 4rj4 | 16 |
| 26 | 6hj | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a | 5j9z | 16 |
| 27 | 3qs | EGFR kinase (T790M/L858R) with inhibitor compound 8 | 4rj8 | 17 |
| 28 | w2r | EGFR Kinase domain T790M/L858R mutant with compound 4 | 3w2r | 19 |
| 29 | 5q4 | EGFR kinase domain mutant ""TMLR"" with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide | 5em7 | 19 |
| 30 | 4yv | EGFR kinase domain mutant ""TMLR"" with compound 1 | 5c8k | 20 |
| 31 | 3r1 | EGFR kinase (T790M/L858R) with inhibitor compound 1 | 4rj7 | 22 |
| 32 | 4z8 | EGFR kinase domain mutant ""TMLR"" with compound 24 | 5cal | 22 |
| 33 | 03p | EGFR Kinase domain complexed with tak-285 | 3poz | 23 |
| 34 | 4yx | EGFR kinase domain mutant ""TMLR"" with compound 23 | 5c8n | 28 |
| 35 | kjv | Crystal structure of EGFR kinase domain in complex with compound 4c | 4jrv | 29 |
| 36 | hyz | Structure of EGFR in complex with hydrazone, a potent dual inhibitor | 2rgp | 30 |
| 37 | 5n4 | EGFR kinase (T790M/L858R) with inhibitor compound 27: ~{N}-(1~{H}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine | 5edr | 34.3 |
| 38 | 63a | EGFR (L858R, T790M, V948R) in complex with 1-[(3R,4R)-3-[({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one | 5hg9 | 35 |
| 39 | w19 | EGFR kinase domain complexed with compound 19b | 3w33 | 36 |
| 40 | 4zg | EGFR kinase domain mutant ""TMLR"" with compound 29 | 5cao | 38 |
| 41 | 4zh | EGFR kinase domain mutant ""TMLR"" with compound 30 | 5cap | 52 |
| 42 | 6hl | EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b | 5j9y | 58 |
| 43 | iti | EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor | 3lzb | 63 |
| 44 | 4yw | EGFR kinase domain mutant ""TMLR"" with compound 17 | 5c8m | 64 |
| 45 | hki | EGFR kinase domain T790M/L858R mutant with HKI-272 | 3w2q | 66 |
| 46 | w32 | EGFR kinase domain complexed with compound 20a | 3w32 | 75 |
| 47 | 3r0 | EGFR kinase (T790M/L858R) with inhibitor compound 4 | 4rj6 | 76 |
| 48 | 4zb | EGFR kinase domain mutant ""TMLR"" with compound 27 | 5can | 124 |
| 49 | 8bm | Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | 5uga | 161 |
| 50 | 8bm | Crystal structure of the EGFR kinase domain in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | 5ugb | 161 |
| 51 | 1e8 | Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib | 5yu9 | 180 |
| 52 | 4zq | EGFR kinase domain with compound 41a | 5cav | 216 |
| 53 | kjr | Crystal structure of EGFR kinase domain in complex with compound 3g | 4jr3 | 218 |
| 54 | 5q2 | EGFR kinase domain mutant ""TMLR"" with pyridone compound 2: 4-[2-(4-chlorophenyl)ethylamino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide | 5em5 | 262 |
| 55 | kjq | Crystal structure of EGFR kinase domain in complex with compound 2a | 4jq7 | 393 |
| 56 | 5q4 | EGFR kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide | 5em8 | 1090 |
| 57 | w2p | EGFR Kinase domain T790M/L858R mutant with compound 2 | 3w2p | 8100 |
| 58 | 03p | EGFR Kinase domain T790M/L858R Mutant with TAK-285 | 3w2o | 8400 |