The Ligandable Human Proteome

Tyrosine-protein kinase SYK

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	x9g	Crystal structure of an inhibitor-bound Syk	4xg9	0.7
2	cg4	Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor	4pv0	0.85
3	4mg	Crystal structure of tyrosine-protein kinase SYK with an inhibitor	4rss	1.7
4	x8g	Crystal structure of an inhibitor-bound Syk	4xg8	1.9
5	7kg	Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)	5tr6	3.2
6	2x6	SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor	4px6	4
7	p5c	Crystal structure of spleen tyrosine kinase complexed with YM193306	3fqe	5
8	7cu	Crystal structure of SYK kinase domain with inhibitor	5tiu	5
9	3yv	SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor	4rx7	5
10	55m	SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor	5cxh	5
11	685	Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)	3emg	9
12	x6g	Crystal structure of an inhibitor-bound Syk	4xg6	9.7
13	x5g	Crystal structure of an inhibitor-bound Syk	5ghv	12.1
14	3yt	SYK Catalytic Domain Complexed with a Potent Pyrimidine Inhibitor	4rx9	13
15	7kf	Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)	5tt7	13
16	1b4	Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide	4i0r	14
17	6zf	HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR	5lmb	15.8
18	55y	SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor	5cy3	16
19	x3g	Crystal structure of an inhibitor-bound Syk	4xg3	17.5
20	0k1	Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor	4dfn	20
21	x4g	Crystal structure of an inhibitor-bound Syk	4xg4	21.5
22	77v	Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine	5t68	23
23	1b6	Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide	4i0t	26
24	3rt	SYK catalytic domain in complex with a potent triazolopyridine inhibitor	4wnm	26
25	s19	Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor	3srv	31.6
26	x7g	Crystal structure of an inhibitor-bound Syk	4xg7	32.6
27	3yx	SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor2	4rx8	35
28	1b5	Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide	4i0s	36
29	585	Crystal structure of spleen tyrosine kinase complexed with R406	3fqs	41
30	0vf	Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1-[7-(3,4-Dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]-pyrrolidin-3-yl}-terephthalamic acid	4fyo	47
31	0vg	Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine	4fz6	127
32	0je	Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416	3vf8	150
33	50h	Crystal structure of SYK in complex with compound 1	5c26	170
34	6zg	HUMAN SPLEEN TYROSINE KINASE KINASE DOMAIN IN COMPLEX WITH AZANAPHTHYRIDINE INHIBITOR	5lma	250
35	55u	SYK catalytic domain complexed with naphthyridine inhibitor	5cxz	552
36	057	Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole	3fqh	570
37	0k0	Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor	4dfl	670
38	sti	Crystal structure of the syk tyrosine kinase domain with Gleevec	1xbb	5000