The Ligandable Human Proteome

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Tyrosine-protein kinase Mer

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
17ysCrystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor5u6c0.05
27aeStructure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate5td22.2
3ckjCrystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC5693tcp4.3
4k0xCrystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC25415k0x4.4
54mhCrystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC18174mha5.2
624kCrystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC19174m3q17
779yStructure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate5tc025
8mh7Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC18964mh75900
9olpCrystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor C523bpr1.13e+004