Index | Ligand Name | Structure | PDB code | Compound Potency nM |
1 | 88z | Structure of the kinase domain of c-Met bound to XL880 (GSK1363089) | 3lq8 | 0.4 |
2 | 0j3 | Crystal structure of CMET in complex with novel inhibitor | 4gg5 | 0.93 |
3 | 1jc | Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog | 4iwd | 1 |
4 | 044 | Crystal structure of c-Met in complex with pyrazolone inhibitor 58a | 3u6i | 1 |
5 | 03x | Crystal structure of c-Met in complex with pyrazolone inhibitor 26 | 3u6h | 1 |
6 | 0jl | Crystal structure of c-Met in complex with triazolopyridinone inhibitor 24 | 4dei | 1 |
7 | 3e8 | Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors | 4r1v | 1 |
8 | 44x | Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole | 4xyf | 1 |
9 | 5t1 | Crystal structure of c-Met in complex with AMG 337 | 5eyd | 1 |
10 | 6xp | Crystal structure of C-MET kinase domain in complex with N'-((3Z)-4- chloro-7-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4- hydroxyphenyl)propanohydrazide | 3zze | 1.3 |
11 | 1fn | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor | 3ce3 | 1.8 |
12 | vgh | X-ray Structure of PF-02341066 bound to the kinase domain of c-Met | 2wgj | 2 |
13 | 5sz | Crystal structure of c-Met in complex with naphthyridinone inhibitor 5 | 5eyc | 3 |
14 | 4k0 | Crystal structure of C-MET kinase domain in complex with 4-(3-((1H- pyrrolo(2,3-b)pyridin-3-yl)methyl)-(1,2,4)triazolo(4,3-b)(1,2,4) triazin-6-yl)benzonitrile | 4aoi | 4 |
15 | m61 | Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog | 3r7o | 4.4 |
16 | 353 | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | 3f82 | 4.6 |
17 | am7 | x-ray structure of c-Met with inhibitor. | 2rfn | 5 |
18 | 63k | Crystal structure of c-Met-M1250T in complex with SAR125844. | 5hor | 6 |
19 | 6xe | X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline. | 3zbx | 6 |
20 | 0jj | Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2 | 4deg | 6 |
21 | 0j8 | Crystal structure of cMET in complex with novel inhibitor | 4gg7 | 6.3 |
22 | dwf | Crystal structure of CMET in complex with novel inhibitor | 4mxc | 6.7 |
23 | l8v | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor | 3l8v | 8 |
24 | l5g | X-ray Structure of c-Met with triazolopyridazine Inhibitor. | 3cd8 | 9 |
25 | 5tf | X-ray Structure of c-Met kinase in complex with inhibitor (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3- b)pyridazin-6-amine | 3zcl | 10.1 |
26 | f47 | Crystal structure of C-MET kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol | 4ap7 | 11 |
27 | mt4 | Structure of c-Met with pyrimidone inhibitor 50 | 3efk | 14 |
28 | b2d | Crystal structure of c-Met with triazolopyridazine inhibitor 13 | 3i5n | 14 |
29 | 3qt | c-Met Kinase in Complex with NVP-BVU972 | 3qti | 14 |
30 | 62e | Crystal structure of c-Met mutant Y1230H in complex with compound 14 | 5hlw | 23 |
31 | q6w | Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor | 3q6w | 27 |
32 | dfq | human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor | 3a4p | 28 |
33 | 320 | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor | 3ctj | 35 |
34 | mt3 | Structure of c-Met with pyrimidone inhibitor 7 | 3efj | 39 |
35 | ckk | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor | 3c1x | 45 |
36 | 1ru | C-Met in complex with OSI ligand | 4knb | 47 |
37 | 63k | Crystal structure of c-Met L1195V in complex with SAR125844 | 5hoa | 64 |
38 | w9z | X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline. | 3zc5 | 74 |
39 | 319 | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor | 3cth | 110 |
40 | lkg | X-ray structure of c-Met with triazolopyridazine inhibitor. | 3ccn | 120 |
41 | 63k | CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD. | 5ho6 | 204 |
42 | 3eh | Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor | 4r1y | 400 |
43 | 0jk | Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3 | 4deh | 612 |
44 | ihx | Human c-Met Kinase in complex with quinoxaline inhibitor | 3f66 | 900 |