The Ligandable Human Proteome

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Mitogen-activated protein kinase 8

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
11j2Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan4izy3
21bkCrystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan4hyu6.2
31bjCrystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan4hys55
41v5Co-crystal Structure of JNK1 and AX135874l7f160
5893Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors2h96230
6aq2Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.4awi1000
738zStructure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode4qtd1080
8myuStructural and functional analysis of quercetagetin, a natural JNK1 inhibitor3v3v4600
9gs7Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.3elj5000