The Ligandable Human Proteome


Mitogen-activated protein kinase 10

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
10f0Discovery of potent and selective covalent inhibitors of JNK3v6s0.75
23nlDesign and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives4whz1
4bz9Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine3da62
5aizinhibitor complex of JNK32b1p3
6kbiCrystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor3tti6
734iDesign and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration3rtp7
8984Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor1pmn7.1
946cCrystal Structure of human JNK3 complexed with an isoquinolone inhibitor2zdt9.6
104f2Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors4y4611
11519Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors4y5h15
12932Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor3ptg25
133whThe MAP kinase JNK3 as target for halogen bonding4x2136
14j07Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors2p3357
153hnJNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide4w4x102.8
163h8JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide4w4v115
17255c-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor2r9s150
18jk3JNK3 bound to piperazine amide inhibitor, SR2774.3fv8160
19jbiCrystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury3ttj210
20jnkInhibitor complex of JNK32exc235
21snbCrystal structure of human Jnk3 complexed with a 1-aryl-3,4- dihydroisoquinoline inhibitor2waj398
223elCrystal structure of human JNK3 in complex with a benzenesulfonamide inhibitor.4u79400
23738Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide2o2u400
24j72JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one3g90440
25cqqDiscovery of potent and selective covalent inhibitors of JNK3v6r709
26j67JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one3g9l740
27j88JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one3g9n1800
28syyDesign and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases3oxi2200
29jnoIRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding3cgo3000
30c0mCrystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide2o0u3200