The Ligandable Human Proteome

Mitogen-activated protein kinase 14

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	b96	Human p38 MAP Kinase in Complex with BIRB 796	1kv2	0.1
2	084	The structure of p38 alpha in complex with a pyridinylimidazole inhibitor	1ouk	0.13
3	p38	Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30	3bv2	0.44
4	p39	Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2	3bv3	0.46
5	b45	The structure of p38alpha in complex with a dihydroquinazolinone	3gc7	0.6
6	358	The structure of p38 alpha in complex with a dihydroquinolinone	1ove	0.74
7	yiw	triazolopyridine inhibitors of p38 kinase	2yiw	0.8
8	a17	P38 complex with a phthalazine inhibitor	3ds6	0.8
9	mih	p38 kinase Crystal structure in complex with small molecule inhibitor	3mw1	0.82
10	f46	Human p38 MAP kinase in complex with a Dibenzoxepinone	4l8m	1
11	09j	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor	3u8w	1
12	i2o	p38 kinase crystal structure in complex with small molecule inhibitor	3rin	1.3
13	hb9	Dibenzosuberone inhibitor 8e in complex with p38 MAPK	5mty	1.3
14	p66	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor	3itz	1.4
15	3ff	Human p38 MAP Kinase in Complex with Skepinone-L	3que	1.5
16	p40	P38 Complexed with a quinazoline inhibitor	3dt1	2.4
17	dqo	Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor	1m7q	2.6
18	ocg	P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor	3ocg	3
19	279	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B	2rg5	3.1
20	p37	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor	3gfe	3.2
21	yix	Triazolopyridine Inhibitors of p38	2yix	3.3
22	304	P38 alpha map kinase complexed with BMS-640994	3bx5	3.5
23	39p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V	3mvm	3.9
24	1pp	p38alpha bound to pyrazolourea	2baj	4
25	nk0	P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor	3s4q	4
26	094	The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor	1ouy	4.3
27	gk6	Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor	3d83	4.4
28	1m8	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE	4kin	4.8
29	tzy	Crystal structure of P38 with triazolopyridine	1zzl	5
30	79q	Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1	5tco	6.46
31	aav	P38ALPHA MAP KINASE BOUND TO CMPD 29	4aac	6.7
32	1r9	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE	4kip	7
33	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)	4loo	7
34	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)	4lop	7
35	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)	4loq	7
36	3nw	P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor	3nww	7
37	6np	Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor	1yqj	7.3
38	469	Human p38 MAP Kinase in Complex with Scios-469	3hub	8.2
39	edd	Crystal structure of P38 alpha in complex with DP802	3nnw	9
40	qc0	P38ALPHA MAP KINASE BOUND TO CMPD 22	4aa4	9
41	1vi	Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b	5ml5	10
42	n4d	P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor	3l8x	10
43	edd	Crystal structure of phosphorylated P38 alpha in complex with DP802	3nnx	11
44	sb2	Dual binding mode of pyridinylimidazole to MAP kinase p38	2ewa	11.5
45	gk5	Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor	3d7z	12
46	lgf	P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds	2qd9	13
47	li9	Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor	1ywr	13
48	38p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K	3mvl	13
49	sb2	Human P38 MAP Kinase in Complex with SB203580	3gcp	15
50	cq0	p38 kinase crystal structure in complex with small molecule inhibitor	3s3i	16
51	nqb	P38ALPHA MAP KINASE BOUND TO CMPD 33	4aa5	16
52	fs8	Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative	3uvq	17
53	fji	Dibenzooxepinone inhibitor 12b in complex with p38 MAPK	5mtx	17.7
54	p7b	p38 inhibitor-bound	3p7b	18
55	sb4	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025	1bl7	19
56	i39	p38 kinase Crystal structure in complex with small molecule inhibitor	3hrb	21
57	p7c	p38 inhibitor-bound	3p7c	22
58	i47	Crystal Structure of Human p38alpha complexed with SD-0006	3hl7	23
59	1ra	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE	4kiq	23
60	sb5	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655	1bmk	25
61	g11	Crystal structure of p38 in complex with a biphenylamide inhibitor	3iph	25.1
62	aa0	P38ALPHA MAP KINASE BOUND TO CMPD 2	4aa0	35
63	048	Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone	3uvp	35
64	aqz	p38alpha MAP kinase bound to MPAQ	2bak	37
65	l9g	Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound	3kf7	40
66	sb2	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580	1a9u	48
67	edb	Crystal structure of P38 alpha in complex with DP1376	3nnu	48
68	bax	Human P38 MAP kinase in complex with Sorafenib	3gcs	56
69	l11	p38 Kinase crystal structure in complex with small molecule inhibitor	1w83	65
70	p5k	P38 inhibitor-bound	3p5k	76
71	bff	Human p38 MAP Kinase in Complex with CP-547632	3l8s	99
72	2a8	Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone	3zya	100
73	3gf	Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate	4r3c	101
74	p78	P38 inhibitor-bound	3p78	110
75	pgj	Mutated Mus Musculus P38 Kinase (mP38)	1yw2	141
76	sb6	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995	1bl6	160
77	bax	P38 in complex with Sorafenib	3heg	180
78	l10	p38 Kinase crystal structure in complex with small molecule inhibitor	1w82	196
79	8en	P38 ALPHA MUTANT C162S IN COMPLEX WITH CMPD2 [N-(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl)benzamide]	5mz3	220
80	1gk	Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor	3mpt	251
81	wbt	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbt	340
82	l09	fragment based p38 inhibitors	1wbn	350
83	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3o8p	350
84	gk4	Crystal structure of P38 in complex with biphenyl amide inhibitor	2zb1	480
85	pqa	p38alpha MAP kinase bound to pyrazoloamine	2bal	490
86	li2	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbs	630
87	pqb	P38 Kinase Crystal Structure in complex with RO3201195	2gfs	700
88	df3	Human p38 MAP Kinase in Complex with an Indole Derivative	3iw5	839
89	g97	Human p38 MAP Kinase in Complex with RL40	3huc	1030
90	bmu	p38 MAP Kinase in Complex with Inhibitor 1	1kv1	1160
91	bi5	Human P38 MAP Kinase in Complex with Inhibitor 1a	1zyj	1500
92	ipk	Human p38 MAP Kinase in Complex with an Imidazo-pyridine	3iw7	2300
93	r39	Human p38 MAP Kinase in Complex with RL39	3hv6	2300
94	p79	P38 inhibitor-bound	3p79	2300
95	irg	Human p38 MAP kinase in complex with RL87	4dli	2400
96	pp0	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol	3iw6	3290
97	msq	THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di9	5000
98	b11	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes	1zz2	6000
99	f4c	P38alpha bound to novel DFG-out compound PF-00416121	3k3j	1.25e+004
100	hiz	Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea	3iw8	1.34e+004
101	sti	P38 in complex with Imatinib	3hec	3.4e+004
102	nar	Human p38 MAP kinase in complex with NP-F2 and RL87	4eh3	2.92e+005
103	0ok	Human p38 MAP kinase in complex with NP-F1 and RL87	4eh2	6.92e+005
104	0om	Human p38 MAP kinase in complex with NP-F4 and RL87	4eh5	8.18e+005