The Ligandable Human Proteome

Dual specificity mitogen-activated protein kinase kinase 1

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	eui	Crystal Structure of MEK1 kinase bound to GDC0973	4lmn	0.05
2	3or	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP	3orn	0.24
3	5y0	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an3	0.6
4	eui	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an2	0.9
5	chu	Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP	3wig	2.3
6	izg	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP	3pp1	3.2
7	yqy	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4anb	6.6
8	v04	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v04	13
9	lsg	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP	3mbl	18
10	vra	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP	3e8n	19
11	5u5	MEK1 IN COMPLEX WITH BI 847325	5eym	25
12	3v0	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v01	25
13	2p7	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an9	44
14	m3k	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP	4ark	63
15	3os	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP	3os3	235
16	22t	Crystal structure of MEK1 in complex with fragment 1	3zm4	1100
17	5ez	Crystal structure of MEK1 in complex with fragment 18	3zlx	1.57e+005