| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 2hx | Pim1 Complexed with a pyridylcarboxamide | 4n70 | 0.001 |
| 2 | 1oc | Structure of PIM-1 kinase bound to N-(5-(2-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-((((3R,4R)-3-fluoropiperidin-4-yl)methyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k1b | 0.003 |
| 3 | 5h7 | Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies | 5dwr | 0.006 |
| 4 | 5e6 | PIM1 in complex with Cpd36 ((1S,3S)-N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)cyclohexane-1,3-diamine) | 5dia | 0.035 |
| 5 | 6yn | Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor. | 5kzi | 0.1 |
| 6 | 3u1 | Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor. | 4wrs | 0.4 |
| 7 | 0f5 | Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design | 3vbq | 0.47 |
| 8 | lxg | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | 3jxw | 1 |
| 9 | unm | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | 3r02 | 1 |
| 10 | 6cb | Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold | 5iis | 1 |
| 11 | 1ob | Structure of PIM-1 kinase bound to 5-(4-cyanobenzyl)-N-(4-fluorophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k18 | 1.1 |
| 12 | 26l | Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors | 4mbl | 2.9 |
| 13 | 55e | Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one | 3dcv | 3 |
| 14 | 596 | Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one | 3umw | 3 |
| 15 | 7li | Novel and selective pan-PIM kinase inhibitor | 4dtk | 3 |
| 16 | lyg | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | 3jy0 | 5 |
| 17 | 3yr | PIM1 kinase in complex with Compound 1s | 4xhk | 5 |
| 18 | r9p | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alv | 7 |
| 19 | 26k | Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors | 4mbi | 7 |
| 20 | vx2 | Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2 | 3bgq | 11 |
| 21 | 3u6 | Crystal structure of human Pim-1 kinase in complex with a thiadiazolamine-indole inhibitor. | 4wt6 | 12 |
| 22 | 676 | Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor | 4bzo | 13 |
| 23 | l20 | Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors | 5dgz | 14 |
| 24 | 1oa | Structure of PIM-1 kinase bound to N-(4-fluorophenyl)-7-hydroxy-5-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | 4k0y | 15 |
| 25 | 2hw | Pim1 Complexed with a pyridylcarboxamide | 4n6z | 16 |
| 26 | 79o | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alu | 17 |
| 27 | hy7 | Benzofuropyrimidinone Inhibitors of Pim-1 | 4alw | 27 |
| 28 | xj1 | Protein kinase Pim-1 in complex with small molecule inibitor | 2xj1 | 28 |
| 29 | que | Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002) | 4lmu | 55 |
| 30 | 985 | Crystal structure of human Pim-1 in complex with DAPPA | 3f2a | 57 |
| 31 | 985 | Protein kinase Pim-1 in complex with small molecule inhibitor | 2xj2 | 66 |
| 32 | 2hv | Pim1 Complexed with a phenylcarboxamide | 4n6y | 92 |
| 33 | unq | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | 3r04 | 120 |
| 34 | 1n6 | Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one | 4jx7 | 123 |
| 35 | q17 | Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002) | 4lm5 | 150 |
| 36 | q17 | Crystal structure of Pim1 kinase in complex with small molecule inhibitor | 3uix | 151 |
| 37 | 6s3 | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | 5kcx | 200 |
| 38 | 3ng | Crystal structure of PIM1 kinase in complex with small-molecule inhibitor | 5o11 | 216 |
| 39 | myu | Crystal structure of Pim1 with Quercetagetin | 2o64 | 340 |
| 40 | 7au | Pim-1 kinase in complex with a 7-azaindole | 5tex | 400 |
| 41 | c2j | Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide | 6ayd | 500 |
| 42 | que | Crystal structure of Pim1 with Quercetin | 2o3p | 1100 |
| 43 | ugx | Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor | 4bzn | 1441 |
| 44 | hul | Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin | 4xh6 | 2710 |