The Ligandable Human Proteome

Proto-oncogene tyrosine-protein kinase Src

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	4a9	Type II Dasatinib Analog Crystallized with c-Src Kinase	4ybj	0.53
2	0jn	Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase	4lgh	2
3	h8h	Src kinase in complex with a quinazoline inhibitor	2h8h	2.7
4	vgg	Structure of 3MB-PP1 bound to analog-sensitive Src kinase	4lgg	3
5	1n1	Kinase domain of cSrc in complex with Dasatinib	3g5d	11
6	4b7	C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase	4ybk	15
7	pd5	Crystal structure of c-Src in complex with pyrazolopyrimidine 5	3el8	25
8	56g	Kinase domain of cSrc in complex with RL235	5d11	28
9	g97	Kinase domain of cSrc in complex with RL40	5d12	43
10	563	Kinase domain of cSrc in complex with RL236	5d10	72
11	djk	Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393	2hwp	73
12	vsp	Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9	3svv	114
13	djk	Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393	3lok	120
14	rbs	Crystal structure of Src kinase domain in complex with covalent inhibitor	2hwo	126
15	11v	Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine	4o2p	200
16	pd3	Crystal structure of c-Src in complex with pyrazolopyrimidine 3	3el7	480
17	i76	c-SRC kinase domain in complex with RM-1-176	4dgg	800
18	mpz	Structure of unphosphorylated c-Src in complex with an inhibitor	1y57	1633
19	sr2	Crystal structure of drug resistant SRC kinase domain with irreversible inhibitor	2qq7	5710
20	sti	Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.	2oiq	1e+004
21	b5a	c-SRC kinase domain in complex with bumpless BKI analog UW1243	3uqg	1e+004
22	bk5	c-SRC kinase domain in complex with BKI RM-1-89	3uqf	2e+004