| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | n66 | TTK kinase domain in complex with NTRC 0066-0 | 5n87 | 0.56 |
| 2 | 8rh | TTK kinase domain in complex with BAY 1217389 | 5nad | 1.1 |
| 3 | 8pt | TTK kinase domain in complex with MPI-0479605 | 5n7v | 1.7 |
| 4 | 8qe | TTK kinase domain in complex with TC-Mps1-12 | 5n93 | 2.2 |
| 5 | 8qw | TTK kinase domain in complex with BAY 1161909 | 5n9s | 2.4 |
| 6 | pwu | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap2 | 3.3 |
| 7 | o38 | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 6-((3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-2-(cyclohexylamino)nicotinonitrile | 3wyx | 4.3 |
| 8 | cq7 | TTK in Complex with Inhibitor | 6b4w | 5 |
| 9 | au5 | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap0 | 5.5 |
| 10 | o43 | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(6-(cyclohexylamino)-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)imidazo[1,2-b]pyridazin-3-yl)-N-cyclopropylbenzamide | 3wzj | 6.6 |
| 11 | 5oe | Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach | 5ei8 | 8 |
| 12 | o38 | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap1 | 10.8 |
| 13 | 8q5 | TTK kinase domain in complex with Mps-BAY2b | 5n84 | 11 |
| 14 | 92m | Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand | 3h9f | 12 |
| 15 | pwu | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap6 | 13.3 |
| 16 | 5nw | Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach | 5eh0 | 18 |
| 17 | dyk | Human TTK in complex with a Dyrk1B inhibitor | 4d2s | 20 |
| 18 | o22 | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide | 3vqu | 37 |
| 19 | 5o7 | Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach | 5ei2 | 46 |
| 20 | o23 | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH N-cyclopropyl-4-(8-((thiophen-2-ylmethyl)amino)imidazo[1,2-a]pyrazin-3-yl)benzamide | 3wzk | 58 |
| 21 | ad5 | Crystal structure of human Mps1 (TTK) in complex with Reversine | 5ljj | 62 |
| 22 | au5 | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap3 | 93 |
| 23 | o38 | Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 5ap4 | 350 |
| 24 | c5n | Crystal structure of human Mps1 (TTK) in complex with Cpd-5 | 5mrb | 471 |
| 25 | cx4 | Crystal structure of human Mps1 catalytic domain in complex with a quinazolin ligand Compound 4 | 3hmp | 3240 |