| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | xld | Crystal Structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazolyl)methylamino]methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa | 1mq6 | 0.007 |
| 2 | lg0 | FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(4-methoxyphenyl)-6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one | 3cs7 | 0.021 |
| 3 | 5qc | Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one | 2fzz | 0.03 |
| 4 | iib | Crystal structure of factor Xa in complex with 21 | 2bq6 | 0.07 |
| 5 | l1d | Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1 | 2w3k | 0.08 |
| 6 | gg2 | Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE | 2p16 | 0.08 |
| 7 | l1c | Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2 | 2w3i | 0.1 |
| 8 | z34 | CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA | 1fjs | 0.11 |
| 9 | 4qc | Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide | 2g00 | 0.18 |
| 10 | ik8 | Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389) | 1z6e | 0.19 |
| 11 | 230 | An Orally Efficacious Factor Xa Inhibitor | 2phb | 0.32 |
| 12 | lgl | Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one | 3kqd | 0.4 |
| 13 | fxv | Crystal Structure of Human Coagulation Factor XA Complexed with FXV673 | 1ksn | 0.4 |
| 14 | riv | Factor Xa in complex with BAY59-7939 | 2w26 | 0.4 |
| 15 | me5 | Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide | 2p95 | 0.43 |
| 16 | me4 | Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide | 2p94 | 0.67 |
| 17 | fxi | The discovery of glycine and related amino acid-based factor xa inhibitors | 2q1j | 0.8 |
| 18 | ffg | Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE | 3ffg | 0.84 |
| 19 | rpr | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 | 1ezq | 0.9 |
| 20 | xlc | Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa | 1mq5 | 1 |
| 21 | gsj | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | 2j4i | 1 |
| 22 | 898 | Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs | 2wyj | 1 |
| 23 | rrr | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685 | 1nfw | 1.1 |
| 24 | rtr | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095 | 1nfy | 1.3 |
| 25 | me1 | Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide | 2p93 | 1.5 |
| 26 | xwg | FACTOR XA - CATION INHIBITOR COMPLEX | 2y5f | 2 |
| 27 | 701 | Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa | 2uwo | 2 |
| 28 | 461 | Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs | 2wyg | 2 |
| 29 | a7i | Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor | 4a7i | 2 |
| 30 | rdr | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208944 | 1nfx | 3 |
| 31 | lzf | Aminopyrrolidine Factor Xa inhibitor | 2vvc | 3 |
| 32 | iia | Crystal structure of factor Xa in complex with compound ""1"" | 2boh | 3 |
| 33 | iie | CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45 | 2bqw | 3 |
| 34 | gsi | Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs | 2vh0 | 3.1 |
| 35 | 443 | Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor | 3kl6 | 3.5 |
| 36 | xbv | Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor | 2xbv | 3.7 |
| 37 | mbm | X-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE | 3k9x | 4 |
| 38 | gsx | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | 2j95 | 4 |
| 39 | 895 | Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa | 2uwl | 4 |
| 40 | fi1 | X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide | 3sw2 | 4.71 |
| 41 | gsk | Crystal structure of a Human Factor Xa inhibitor complex | 2cji | 6 |
| 42 | h21 | Aminopyrrolidine-related triazole Factor Xa inhibitor | 2vvv | 6 |
| 43 | yet | Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine | 3hpt | 6.5 |
| 44 | d90 | Factor Xa in complex with a phenylenediamine derivative | 3q3k | 7.4 |
| 45 | h22 | Aminopyrrolidine Factor Xa inhibitor | 2vvu | 8 |
| 46 | lgm | Factor xa in complex with the inhibitor 3-methyl-1-(3-(5- oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1-ylmethyl)biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)-one | 3kqe | 8.1 |
| 47 | ens | Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate | 3ens | 8.9 |
| 48 | ivk | Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor | 2xc4 | 9 |
| 49 | bi7 | Factor Xa - cation inhibitor complex | 2jkh | 9 |
| 50 | d14 | Factor XA in complex with a cis-1,2-diaminocyclohexane derivative | 3iit | 9.5 |
| 51 | 455 | Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor | 2xbw | 10 |
| 52 | h25 | Aminopyrrolidine Factor Xa inhibitor | 2vwn | 10 |
| 53 | 4o6 | Factor Xa complex with GTC000406 | 4y79 | 11 |
| 54 | rr8 | Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor | 2xbx | 15 |
| 55 | gs6 | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | 2j34 | 15 |
| 56 | jnj | X-ray Structure of FXa in complex with 7-fluoroindazole | 2ra0 | 15.9 |
| 57 | i1h | Crystal structure of factor Xa in complex with 50 | 2bmg | 18 |
| 58 | d91 | Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine | 1wu1 | 18 |
| 59 | pr2 | Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707 | 1f0s | 18 |
| 60 | rrp | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747 | 1nfu | 18 |
| 61 | 815 | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 | 1f0r | 22 |
| 62 | d76 | Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine | 1v3x | 24 |
| 63 | lzg | Aminopyrrolidine Factor Xa inhibitor | 2vwo | 31 |
| 64 | dx9 | COAGULATION FACTOR XA INHIBITOR COMPLEX | 1fax | 41 |
| 65 | d92 | FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine | 2ei6 | 41 |
| 66 | gsq | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | 2j2u | 47 |
| 67 | t87 | FACTOR XA INHIBITOR COMPLEX | 1g2l | 57 |
| 68 | iid | Crystal structure of factor Xa in complex with 43 | 2bq7 | 89 |
| 69 | lzi | Aminopyrrolidine Factor Xa inhibitor | 2vwm | 93 |
| 70 | lzh | Aminopyrrolidine Factor Xa inhibitor | 2vwl | 95 |
| 71 | 4pp | FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | 1xka | 131 |
| 72 | fjd | FACTOR XA - CATION INHIBITOR COMPLEX | 2y5g | 146 |
| 73 | 894 | Factor Xa inhibitor complex | 2uwp | 154 |
| 74 | 784 | Factor Xa - cation | 2bok | 280 |
| 75 | g15 | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | 2j94 | 534 |
| 76 | y5h | FACTOR XA - CATION INHIBITOR COMPLEX | 2y5h | 1620 |