The Ligandable Human Proteome

Prothrombin

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	170	crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor	1sl3	0.0014
2	00l	HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN	1a5g	0.071
3	l86	thrombin in complex with selective macrocyclic inhibitor at 1.8A	1nm6	0.09
4	33u	Bisphenylic Thrombin Inhibitors	2zo3	0.1
5	110	CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE	1g37	0.1
6	0kv	Thrombin inhibitors with rigid tripeptidyl aldehydes	1ca8	0.32
7	t15	Crystal structure of thrombin in complex with inhibitor 15	3c1k	0.36
8	l17	thrombin and P2 pyridine N-oxide inhibitor complex structure	1z71	0.66
9	177	Crystal structure of thrombin in complex with compound 14b	1ta6	0.74
10	bzt	CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 4	1d3d	0.81
11	m4z	Thrombin in complex with inhibitor	4baq	0.98
12	3sp	Orally active thrombin inhibitors	2fes	0.98
13	cdb	thrombin-hirugen_l-378,650	1mu8	1
14	mm9	Thrombin in complex with inhibitor	4bam	1.14
15	m67	Thrombin in complex with inhibitor	4bak	1.22
16	t76	thrombin in complex with selective macrocyclic inhibitor	1nt1	1.3
17	34p	orally active thrombin inhibitors	2feq	1.39
18	cdo	Ternary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor	2anm	1.8
19	701	Human Thrombin Hirugen Inhibitor complex	2jh0	2
20	mel	Thrombin in complex with inhibitor	4bah	2.01
21	cdd	Thrombin-Hirugen-L405,426	1mue	2.3
22	00n	THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR	1a61	2.4
23	m6s	Thrombin in complex with inhibitor	4ban	2.43
24	176	Crystal structure of thrombin in complex with compound 1	1ta2	3
25	c2d	Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker	2bxt	3
26	c7m	thrombin inhibitors	2c8w	3.7
27	mel	HUMAN THROMBIN-INHIBITOR COMPLEX	1k22	4
28	32u	Exploring Thrombin S1 pocket	2zda	4
29	ign	HUMAN THROMBIN-INHIBITOR COMPLEX	1k21	4.2
30	mvf	Thrombin in complex with inhibitor	4bao	4.29
31	0iv	THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES	1bb0	4.4
32	min	ALPHA-THROMBIN COMPLEXED WITH HIRUGEN	1tom	5
33	bai	RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES	1c1u	5.6
34	163	Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor	1o0d	6.2
35	mid	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS	1dwd	6.6
36	d6j	Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-((1S)-2-((4- carbamimidoylphenyl)methylamino)-1-methyl-2-oxo-ethyl)-N-methyl-3- phenyl-propanamide ethane	4ufg	7
37	3zd	Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-butyl)-3-phenyl-propanamide	4ufe	7
38	121	A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE	1ghy	8
39	gr1	Novel Covalent Active Site Thrombin Inhibitors	1qj7	8
40	uip	Thrombin Inhibitor Complex	1ype	8
41	esh	Complex of recombinant human thrombin with an inhibitor	2cf8	8
42	0bm	Human alpha-thrombin complexed with N-(methylsulfonyl)-D-phenylalanyl-N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (BMS-189664)	3tu7	8.17
43	166	Novel Covalent Active Site Thrombin Inhibitors	1qj1	9
44	45s	Thrombin in complex with (S)-(4-chloro-2-((1-(5-methyl-1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium	4yes	9.6
45	0ze	HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN	1b5g	10
46	uir	Thrombin Inhibitor Complex	1ypg	10
47	6v2	Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-ethyl)-N-methyl-3-phenyl- propanamide	4uff	11
48	162	D-Phe-Pro-Arg-Type Thrombin Inhibitor	1nzq	11
49	bli	CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR	1jwt	14
50	348	Complex of recombinant human thrombin with an inhibitor	2cf9	15
51	unb	thrombin in complex with inhibitor	2bdy	17
52	894	Human Thrombin Hirugen Inhibitor complex	2jh6	17
53	167	Novel Covalent Active Site Thrombin Inhibitors	1qj6	18
54	na9	Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12	2a2x	20.2
55	14a	Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin	1t4v	21
56	f25	Complex of Recombinant Human Thrombin with a Designed Inhibitor	2cn0	22
57	shy	Complex of thrombin with designed inhibitor 7165	1vzq	36
58	mit	CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS	1dwc	39
59	bt3	CRYSTAL STRUCTURE OF HUMAN APLHA-THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 3	1d3p	41
60	23u	Bisphenylic Thrombin Inhibitors	3dhk	47
61	9mu	Human thrombin - inhibitor complex	4az2	47
62	i50	2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors	2r2m	47.1
63	n12	orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide	2ank	47.3
64	fsn	COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR	1oyt	57
65	c1d	Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker	2bxu	70
66	uib	Thrombin Inhibitor Complex	1ypj	95
67	64u	Understanding Thrombin Inhibition	3dux	100
68	165	Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics	1sb1	128
69	t87	THROMBIN INHIBITOR COMPLEX	1g30	140
70	29u	Thrombin Inhibition	2zgx	180
71	22u	Thrombin in complex with Inhibitor	2zc9	180
72	c5m	thrombin inhibitors	2c8x	220
73	bt2	CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 2	1d3q	290
74	895	Human Thrombin Hirugen Inhibitor complex	2jh5	367
75	bpp	CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5-AMIDINOINDOLE-4-BENZYLPIPERIDINE INHIBITOR	1d4p	500
76	apa	CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION	1aht	620
77	r11	THROMBIN INHIBITOR COMPLEX	1g32	780
78	00r	STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1	1d6w	1100
79	c02	Thrombin inhibitor complex	1ktt	1500
80	b01	Human Thrombin In Complex With UBTHR101	3shc	1900
81	00k	THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR	1a46	2000
82	p97	Human Thrombin In Complex With UBTHR97	3sha	2600
83	44u	Crystal structure of thrombin in complex with inhibitor	3da9	3100
84	i11	BOVINE THROMBIN--BM51.1011 COMPLEX	1uvs	4000
85	ppx	CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR	1qbv	4100
86	382	thrombin in complex with an oxazolopyridine inhibitor 21	1zgi	4600
87	19u	Thrombin Inibition	2zfp	6800
88	miu	Alpha-thrombin complex with sulfated hirudin (residues 54-65) and L- Arginine template inhibitor CS107	1w7g	8000
89	91u	Thrombin Inhibition	3f68	8700
90	cr9	Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)	1o5g	1.1e+004
91	c4m	thrombin inhibitors	2c93	1.2e+004
92	06p	Thrombin Inhibition by Pyridin Derivatives	3qtv	2.25e+004
93	99p	Thrombin Inhibition by Pyridin Derivatives	3p17	3.34e+004
94	98p	Thrombin Inhibition by Pyridin Derivatives	3qwc	5.54e+004
95	02p	Thrombin Inhibition by Pyridin Derivatives	3qx5	6.35e+004
96	p05	Human Thrombin In Complex With UBTHR105	3sv2	6.4e+004
97	b03	Human Thrombin In Complex With UBTHR103	3si3	6.93e+004
98	10p	Thrombin Inhibition by Pyridin Derivatives	3qto	7.48e+004
99	2ce	Human thrombin complexed with fragment-based small molecules occupying the S1 pocket	2bvs	8e+004
100	b04	Human Thrombin In Complex With UBTHR104	3si4	1.322e+005
101	4cp	Human thrombin complexed with fragment-based small molecules occupying the S1 pocket	2bvr	2e+005