The Ligandable Human Proteome

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Ubiquitin carboxyl-terminal hydrolase 7

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IndexLigand NameStructurePDB codeCompound Potency nM
18wkCrystal structure of USP7 in complex with the non-covalent inhibitor, FT6715nge65
29qdStructure of DUB complex5vs6104
38qqCrystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor5n9t220
48jmUSP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)5uqv430
58jpUSP7 in complex with GNE6776 (6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide)5uqx610
68rnCrystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor5n9r2600
79qaStructure of DUB complex5vsb7614
88wnCrystal structure of USP7 in complex with the covalent inhibitor, FT8275ngf7800
9ajjUSP7 in complex with Cpd2 (4-(3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl)phenol)5whc1.2e+004