| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 19f | PDE2 catalytic domain complexed with inhibitors | 5u7d | 0.5 |
| 2 | 9ga | Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders | 5vp1 | 0.51 |
| 3 | 9gj | Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders | 5vp0 | 0.61 |
| 4 | 7og | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A WITH 3-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-1-[(naphthalene-2-yl)carbonyl]piperidine | 5tza | 1 |
| 5 | 788 | PDE2a catalytic domain in complex with a brain penetrant inhibitor | 4d09 | 1.7 |
| 6 | 7ov | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluoro-3-iodophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5u00 | 2 |
| 7 | 19f | Crystal structure of PDE2 catalytic domain in complex with BAY60-7550 | 4htx | 4.7 |
| 8 | 7y1 | PDE2 catalytic domain complexed with inhibitors | 5u7k | 7.1 |
| 9 | 7oj | Crystal Structure of human PDE2a in complex with (5S)-1-[(3-bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5tzc | 8 |
| 10 | q2t | PDE2a catalytic domain in complex with a brain penetrant inhibitor | 4d08 | 10 |
| 11 | 7oj | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3-bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5tzz | 14 |
| 12 | czv | Crystal Structure of PDE2 in complex with compound 16 | 6b96 | 14.3 |
| 13 | 87r | Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | 5xkm | 24 |
| 14 | 1l6 | Crystal structure of of PDE2-inhibitor complex | 4jib | 45 |
| 15 | 7oy | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3-chloro-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5tzx | 52 |
| 16 | 7xs | PDE2 catalytic domain complexed with inhibitors | 5u7i | 66.6 |
| 17 | 7om | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX with [1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-N-(naphthalene-2-yl)piperidine-3-carboxamide | 5tz3 | 140 |
| 18 | czy | Crystal structure of PDE2 in complex with complex 9 | 6b97 | 237 |
| 19 | 7xv | PDE2 catalytic domain complexed with inhibitors | 5u7j | 389.6 |
| 20 | 7y4 | PDE2 catalytic domain complexed with inhibitors | 5u7l | 423 |
| 21 | 7op | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5tzh | 679 |
| 22 | 7p4 | CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 1-[(3,4-difluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 5tzw | 987 |
| 23 | ibm | hPDE2A catalytic domain complexed with IBMX | 3itu | 4e+004 |