The Ligandable Human Proteome

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Index	Ligand Name	Structure	PDB code	Compound Potency nM
1	pil	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast	1xon	0.021
2	m98	Crystal structure of PDE4D in complex with L-869298	2fm0	0.4
3	ihm	Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide	3v9b	0.5
4	rof	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast	1xoq	0.68
5	d71	Crystal structure of human phosphodiesterase 4d with d155871	3g4i	0.91
6	15x	Crystal structure of human phosphodiesterase 4D with bound allosteric modulator	3iad	1
7	3kq	PDE4 complexed with inhibitor	4wcu	3
8	rof	Crystal structure of human phosphodiesterase 4d with roflumilast	3g4l	5.8
9	6pt	PDE4 crystal structure in complex with small molecule inhibitor	5k1i	9.2
10	cio	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast	1xom	11
11	7dj	CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND	5tkb	13
12	j25	Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d	3sl5	22
13	jn4	Crystal structure of the catalytic domain of PDE4D2 with compound 10D	3sl4	27
14	m99	Crystal structure of PDE4D2 in complex with inhibitor L-869299	2fm5	43
15	rol	Crystal structure of human phosphodiesterase 4d with rolipram	3g4k	288
16	jn7	Crystal structure of the catalytic domain of PDE4D2 with compound 10o	3sl8	290
17	rol	Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity	1q9m	330
18	rol	Crystal structure of PDE4D2 in complex with (R,S)-rolipram	1oyn	550
19	ibm	Structure of PDE4D2-IBMX	1zkn	3.1e+004